16 Anandamide Supplements That Boost Mood and Wellness

Discover the best anandamide supplement to elevate your wellness naturally. Quick, effective, and crafted for your optimal mind and body harmony.
BrandMy RatingPrice
Humbleroots Performance
Most Cost-Effective
9.2/10
Tesseract Medical Research
Best for Stress Relief
7.4/10
Immunocorp
Best for Mood Enhancement
N/A
Puritan's Pride
Best for Calm & Relaxation
9.2/10
Sun Potion
8.4/10

Best Anandamide Supplement

Discover the secret to elevating your mood and enhancing overall well-being with the best anandamide supplements on the market. These natural enhancers aim to unlock your body's blissful potential, blending science with nature to create a harmonious uplift. Dive into our quick guide to find the perfect supplement to boost your inner euphoria with ease and confidence.

Most Cost-Effective: HUMBLEROOTS Performance

8-IN-1 All-Natural Nootropic Supplement for Focus, Energy, & Memory Support | Organic Lion's Mane & Rhodiola | Cognizin Citicoline & CognatiQ | Caffeine & L-Theanine | Huperzine-A & Vitamin B12
Highlights
Enhanced cognitive function
Steady, natural energy
Supports brain health

As the most cost-effective option on our list, it packs a punch with 1000mg NAD+ per serving, supporting cellular energy and brain health without breaking the bank.

The powerful blend of organic Lion’s Mane, Rhodiola, and Cognizin Citicoline provides clear mental sharpness, enhanced focus, and neuroprotection.

Plus, its natural energy boost rivals a cup of coffee, making it perfect for quick mental clarity or pre-workout performance.

While it does contain caffeine, we found the effects steady and energizing, with minimal jitters when dosed appropriately.

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Price history for HUMBLEROOTS Performance on Amazon

Best for Stress Relief: Tesseract Medical Research AnaQuell

Tesseract Medical Research AnaQuell QR, Stress Relief & Mood Support Supplement, Quick Release L Citrulline & Anandamide, Helps Manage Anxiousness, 45 V-Caps, Size Exclusive to Amazon
Highlights
Effective stress support
Subtle calming effects
High absorption technology

AnaQuell stands out with its innovative nano-molecular delivery system, ensuring rapid and effective absorption of Anandamide and L Citrulline.

The subtle calming effects help ease stress and promote a sense of mental well-being without overwhelming drowsiness.

While the price is on the higher side, the advanced formulation and high bioavailability justify the investment if you're seeking quick, noticeable relief from daily tension.

Keep in mind, results vary, but for tech-savvy stress support, AnaQuell is a compelling choice that pushes the boundaries of traditional supplements.

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Price history for Tesseract Medical Research AnaQuell on Amazon

Best for Mood Enhancement: Immunocorp Anandatol

ANANDATOL® - Natural Hemp Extract Supplement to Support Relaxation, Mood Balance & Stress Reduction | Enhance Anandamide with Organic Black Pepper, Clove, Rosemary | 30 Caplets
Highlights
Promotes Calmness
Natural Mood Boost
Organic, Chemical-Free

ANANDATOL delivers on its promise to promote calmness and mood enhancement with its thoughtfully selected organic botanicals.

The combination of hemp extract and herbs like black pepper, clove, and rosemary helps boost anandamide naturally, supporting emotional balance without any harsh chemicals.

Its convenient capsule form makes daily stress management simple.

While the higher price tag might give some pause and the limited weight isn’t ideal for long-term use, we found its clean, organic formula to be a worthwhile choice for anyone seeking a natural, chemical-free mood booster.

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Price history for Immunocorp Anandatol on Amazon

Best for Calm & Relaxation: Puritan's Pride Zeaxanthin & Lutein

Puritan's Pride Zeaxanthin 4mg With Lutigold™ Lutein 10mg Carotenoids, Dietary Supplement for Healthy Eyes and Vision, 60 Easy-To-Swallow Rapid Release Softgels
Highlights
Supports eye health
Affordable and trusted
Reduces dry eyes

… It’s rich in natural carotenoids and antioxidants, making it a powerful supporter of eye health.

We love how it nourishes a healthy macula and helps maintain clear, sharp vision—perfect for those who want to protect their eyes daily.

Plus, it supports the photoreceptors, ensuring your eyes stay resilient.

But what really caught our attention is its natural calming effect—helping us feel a little more relaxed amidst busy days.

While it's not a comprehensive solution for all health concerns, for targeted eye support combined with a calming boost, it’s an excellent choice.

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Price history for Puritan's Pride Zeaxanthin & Lutein on Amazon

Sun Potion

Organic Anandamide 222g by Sun Potion - Raw Unsweetened Cacao Powder and Tonic Herbs - Includes Tocos Ashwagandha Reishi Maca Moringa Turmeric Astragalus Cayenne Cinnamon and Others
Highlights
Organic, small batches
Rich, spiced flavor
Contains adaptogens

This alchemical blend beautifully combines organic ingredients with an artful mix of adaptogens like Ashwagandha, Reishi, and Moringa, making it a versatile choice for balancing mind and body.

The rich, spiced, and creamy hot chocolate flavor makes each dose feel like a cozy treat—sweeten to taste or enjoy as-is.

While the serving size can vary, the overall quality and intention behind small-batch crafting shine through.

Though it comes with a higher price tag and isn't purely Anandamide, its healing harmony and handcrafted care make it a distinctive addition for those seeking an herbal complement to wellness.

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Price history for Sun Potion on Amazon

Double Wood

Astaxanthin 12mg Max Strength (AstaReal: Natural Patented Astaxanthin with 70+ Human Clinical Trials - World's Most Studied Brand) Grown, Harvested, and Made in The USA (Astaxantina) by Double Wood
Highlights
High potency (12mg)
Clinically studied brand
Supports multiple health areas

Double Wood's Astaxanthin stands out thanks to its high 12mg potency per softgel, backed by over 70 human clinical trials from the reputable AstaReal brand.

It’s a true multitasker, supporting skin, aging, immune function, eye health, and recovery after workouts.

Plus, with a two-month supply, it offers great value for consistent use.

While some may experience mild skin yellowing, it’s a small trade-off for the potent antioxidant power — 1.6x stronger than Lycopene and thousands of times more powerful than Vitamin C.

Overall, a reliable choice for premium antioxidant support.

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Price history for Double Wood on Amazon

Integrative Therapeutics HPA Adapt Anandamide Supplement

Integrative Therapeutics HPA Adapt - Supports a Healthy Stress Response* - Positive Outlook Supplement with Ashwagandha, Maca, Holy Basil & Rhodiola - Gluten-Free & Soy-Free - 120 Vegan Capsules
Highlights
Supports stress relief
Boosts mood and motivation
Contains adaptogenic herbs

HPA Adapt by Nature's Way harnesses a powerful mix of adaptogenic herbs like Ashwagandha, Maca, and Rhodiola, designed to help your body handle stress more gracefully.

It supports your hormonal balance and promotes a calmer mood, perfect for those busy, stressful days.

Plus, it’s vegan, gluten-free, and free from artificial nasties, making it suitable for many lifestyles.

While individual results can vary and the review pool is still small, we found it effective at providing a subtle, balanced boost to stress resilience, without any jitters or crash.

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Price history for Integrative Therapeutics HPA Adapt on Amazon

Sports Research L-Theanine

Sports Research Double Strength L-Theanine Supplement - Suntheanine Softgels for Focus, Relaxation & Alertness - Non-Drowsy Support Made with Coconut Oil, Non-GMO & Gluten Free - 200mg, 60 Count
Highlights
Calms without jitters
Double strength potency
Supportive for focus

The double-strength 200 mg dose provides a much-needed boost to focus and calmness without any of the jitters typically associated with stimulants.

The use of patented Suntheanine ensures a smooth, sustained relaxation that promotes alpha brain waves, making it perfect for work or unwinding.

Plus, its crafted with premium organic ingredients and manufactured in the USA according to strict standards, giving us peace of mind.

While some users report heat sensitivity during transit and fused capsules, the overall experience remains positive with a solid 4.5-star rating.

For those seeking a natural, non-drowsy calm, this supplement earns our recommendation.

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Price history for Sports Research L-Theanine on Amazon

Genobbely NAD+

800 mg Liposomal NAD+ Supplement with Nicotinamide Riboside 200 mg, Trans-Resveratrol 100 mg - True NAD Supplement for DNA Repair, Healthy Aging, Brain Function - 60-Day Supply
Highlights
High bioavailability trans-resveratrol
Rapid absorption technology
Supports healthy aging

GENOBBELY's Liposomal NAD+ is a game-changer in the anti-aging supplement scene.

Its high bioavailability trans-resveratrol, combined with liposome technology, ensures rapid absorption and maximum effectiveness.

The inclusion of 500 mg True NAD+ and 200 mg Nicotinamide Riboside provides essential support for cellular energy and healthy aging.

Plus, the softgel formulation makes swallowing a breeze, and it’s free from artificial additives, GMOs, and common allergens.

While a few users noted occasional melting or subtle effects, the overall quality and innovative delivery system make this a strong choice for those fighting Father Time.

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Price history for Genobbely NAD+ on Amazon

Integrative Therapeutics L-Theanine Anandamide Supplement

Integrative Therapeutics L-Theanine - L-Theanine to Support a Relaxed State* - Healthy Stress Response* - Vegan & Gluten-Free Amino Acid Supplement - 200 mg, 60 Capsules
Highlights
Supports relaxation
High-quality from trusted brand
Vegan, soy & dairy free

Integrative Therapeutics has a long-standing reputation for quality, and this L-Theanine supplement is no exception.

It promotes a calm, relaxed state without making you feel sluggish, ideal for those who want to stay alert but avoid stress.

Plus, it’s vegan, soy-free, and dairy-free, making it suitable for various diets.

However, some users report dizziness or vivid dreams, and it might be too sedative for daytime use if you're sensitive.

Overall, a trustworthy choice that supports relaxation with a gentle touch—perfect for winding down.

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Price history for Integrative Therapeutics L-Theanine on Amazon

Pure Encapsulations Pregnenolone

Pure Encapsulations Pregnenolone - 30 mg - Hormone Support - Memory Support & Brain Supplement - Gluten Free & Vegan - 180 Capsules
Highlights
Hormone balance support
Enhances memory wellness
Vegan, gluten-free

Pure Encapsulations Pregnenolone 30 mg is a standout for those seeking hormonal support and cognitive enhancement.

It’s crafted with premium vegan ingredients, ensuring quality while removing common allergens and unnecessary additives.

The versatile dosage options let you tailor your intake, whether you’re aiming for memory boost or hormonal balance.

While some might experience absorption issues or find it not suitable for everyone, its clean formula and strong ratings make it a worthwhile choice for many.

If you're after a trusted, clean supplement that supports both mind and body, this one deserves your consideration.

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Price history for Pure Encapsulations Pregnenolone on Amazon

Tru Niagen

TRU NIAGEN Patented NAD+ Supplement for Anti Aging and Cell Regeneration, 300 mg Niagen, 30 Servings | Supports Cellular Energy, Brain, Muscle | Nicotinamide Riboside (NR) Take 1 Daily | 1 Bottle
Highlights
Supports cellular health
Clinically proven safety
Boosts energy naturally

Tru Niagen stands out as a superior anti-aging supplement thanks to its patented NAD+ boosting technology.

It’s clinically proven to increase NAD+ levels by over 50% in just two weeks, supporting your cells’ ability to repair and rejuvenate.

Its rigorous safety testing and decades of research backed by Nobel laureates make it a trustworthy choice.

While the price tag is on the higher side, the long-term benefits for cellular health and energy make it a worthwhile investment for those serious about aging gracefully.

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Price history for Tru Niagen on Amazon

HPN NAD+ Booster Anandamide Supplement

HPN NAD+ Booster (NAD3), Anti Aging Cell Booster, NRF2 Activator, Nicotinamide Riboside Alternative, NAD Supplement Natural Energy, Longevity, and Cellular Health, 312 Mg per Serving (1 Month Supply)
Highlights
Supports cellular health
Boosts energy levels
Improves skin appearance

NAD(3) stands out as the most effective NAD+ booster on the market, thanks to cutting-edge science that surpasses traditional nicotinamide riboside.

It actively supports cellular energy, promotes healthy aging, and enhances skin vitality.

Made in the USA with rigorous independent testing, NAD(3) guarantees purity and quality.

While it does carry a higher price tag and limited reviews, the proven benefits for mitochondrial health and DNA protection make it a top contender for anyone serious about longevity and vitality.

Overall, NAD(3) is a powerhouse for cellular renewal.

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Price history for HPN NAD+ Booster on Amazon

aSquared Nutrition

aSquared Nutrition Nicotinamide with Resveratrol - 120 Veggie Capsules - Vitamin B3 500mg (Niacinamide Flush Free) - Supplement Pills to Support NAD, Skin Cell Health & Energy
Highlights
Supports cellular health
Boosts energy levels
Enhances longevity

It combines 500mg of Non-Flush Nicotinamide with 100mg of Resveratrol to support cellular repair, longevity, and wellness.

The potent, proprietary blend enhances energy production and helps maintain NAD+ levels, crucial for fighting age-related decline.

Plus, it’s vegan-friendly, gluten-free, and offers a generous 120 capsules per bottle—no skimping here.

While some users may experience mild stomach upset, the overall positive reviews and strength of ingredients make it a standout choice for those seeking a natural, longevity-boosting supplement.

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Price history for aSquared Nutrition on Amazon

Deal Supplement NAD+

NAD+ Supplement 1,000mg Per Serving, 120 Veggie Capsules – Extra Strength, Boosts NAD+ Levels – Healthy Aging, Energy, & Brain Support – Similar to Nicotinamide Riboside – Non-GMO
Highlights
Supports Vitality
High Absorption Rate
Pure & Tested

The NAD+ 1,000mg veggie capsules from Deal Supplement deliver a powerful punch in supporting natural NAD replenishment — vital as we age.

The high absorption rate makes it easier for your body to utilize, boosting energy, brain function, and cellular health.

Plus, it’s made with non-GMO, thoroughly tested ingredients, ensuring quality and safety.

While the capsule size might take a little adjusting and the price is on the higher side, the potential benefits for vitality and healthy aging make it worth considering.

Overall, a solid choice for anyone looking to optimize their energy naturally.

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Price history for Deal Supplement NAD+ on Amazon

Deal Supplement Vitamin B3 Anandamide Supplement

Vitamin B3 Nicotinamide 1,000mg Per Serving – 500 Capsules, Flush Free Niacin, Essential B3 – Supports Healthy Skin & Energy Production – Non-GMO
Highlights
High strength dosage
No flushing effects
Long-lasting supply

This supplement delivers a powerful 1,000mg of bioavailable nicotinamide per serving, making it ideal for those needing a boost in B3 without the typical flushing sensation.

The water-soluble form ensures excellent absorption, and the long-lasting 250-day supply means you'll stay stocked up with minimal fuss.

Plus, its flush-free formula is gentle on the skin and perfect for daily use.

The capsules are a bit larger, but that’s a small price to pay for the extra strength and peace of mind with non-GMO, third-party tested ingredients.

Overall, it’s a reliable choice for energy, skin, and heart support without the unwanted side effects.

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Price history for Deal Supplement Vitamin B3 on Amazon

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