17 BDNF Supplements That Boost Brain Power

Discover the best BDNF supplements to boost brain health and enhance focus. Find top picks for a sharper mind and vibrant mental clarity today.
BrandMy RatingPrice
Bronson
Top Low-Cost Selection
9.0/10
Researched Nutritionals
Best for Brain Health
9.4/10
Double Wood Supplements
Best for Cognitive Focus
9.0/10
Thorne
Best for Neuroplasticity Support
8.0/10
Naomi
8.8/10

Best Bdnf Supplements

Looking to boost your brainpower and unlock mental clarity? Dive into our curated guide of the best BDNF supplements, crafted to energize your neurons and ignite your cognitive potential. Quick, concise, and loaded with insights—we've got your focus and memory covered with top-tier options.

Top Low-Cost Selection: Bronson Ginkgo Biloba

Bronson Ginkgo Biloba Extra Strength Supports Brain Function & Memory Support, 120 Vegetarian Capsules
Highlights
Supports brain health
Effective focus & memory
Trusted since 1960

As our "Top Low-Cost Selection," Bronson Ginkgo Biloba delivers a large volume of capsules at an affordable price, making brain support accessible without breaking the bank.

The supplement is backed by trusted brand history since 1960 and undergoes rigorous quality control to ensure purity, potency, and safety.

While the large pills might be a bit challenging to swallow for some, the effectiveness in boosting focus and memory makes it a worthwhile choice.

Plus, trusted manufacturing standards give us peace of mind knowing we're choosing a reliable option for cognitive health.

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Best for Brain Health: Researched Nutritionals

Researched Nutritionals Brain Supplements for Memory & Focus Support - BDNF Essentials - Bacopa Monnieri, Organic Lion's Mane & Herbal Supplements to Promote Healthy Cortisol Levels (120 Capsules)
Highlights
Clinically researched formula
Supports neuroplasticity
Vegetarian and Non-GMO

BDNF Essentials truly lives up to its reputation as the "Best for Brain Health." Its clinically researched formula combines organic lion's mane and herbal extracts to support memory, neuroprotection, and brain cellular health.

Plus, with added focus on maintaining healthy cortisol levels, it helps improve mental clarity and focus throughout the day.

We also appreciate that it is vegetarian and Non-GMO, making it accessible and ethically sound.

While the proprietary blend keeps some details under wraps, the peer-reviewed science backing its benefits gives us confidence in its effectiveness.

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Best for Cognitive Focus: Double Wood Supplements Lions Mane

Lions Mane Supplement Mushroom Capsules (Two Month Supply - 120 Count) Lions Mane Mushroom for Brain Support and Immune Health (Third Party Tested, Grown and Encapsulated in The USA) by Double Wood
Highlights
Supports neurogenesis
Enhances mood and focus
Pure, potent, quality

Double Wood's Lion’s Mane is our pick for "Best for Cognitive Focus" thanks to its potent blend of neuro-supporting ingredients.

The lion’s mane mushroom is renowned for supporting nerve growth and boosting BDNF levels, which translates to better mood, sharper focus, and enhanced mental clarity.

Plus, the supplement is a two-month supply, offering great value and a steady boost to your brain health.

While some users might experience allergies or subtle effects, the overall quality and purity make this a standout choice for those looking to optimize concentration and mental performance.

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Price history for Double Wood Supplements Lions Mane on Amazon

Best for Neuroplasticity Support: Thorne Brain Factors

THORNE Brain Factors - Brain Health Supplement with Nicotinamide Riboside, Coffee Fruit Extract, and Betaine Anhydrous - Supports Learning, Memory and Cognition - 30 Capsules
Highlights
Supports brain health
Enhances cognition and memory
Trusted manufacturer

As the best for neuroplasticity support, it combines powerful ingredients like Nicotinamide Riboside and herbal BDNF support to promote neural growth and brain adaptability.

It’s designed to keep your mind sharp by boosting BDNF and NAD+, which are crucial for learning, memory, and cellular energy.

Plus, the Coffee Fruit Extract helps maintain healthy BDNF levels, supporting cognitive functions.

While the evidence for BDNF increase isn’t rock-solid, we appreciate the focus on healthy aging and brain health.

A trusted choice for anyone aiming to stay mentally agile!

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NAOMI Brainspan

NAOMI Brainspan™ with BDNF Boost - Fast-Acting Support for Healthy Brain Function & Performance, Lion's Mane Mushroom, Gingko Biloba Extract, Gaden Sage, Spanish Sage - 60 Capsules, 30-Day Supply
Highlights
Supports multiple brain functions
Contains clinically backed ingredients
Stimulant-free and safe

Naomi BrainSpan offers comprehensive support for six crucial signs of brain wellness, from memory to reaction time.

Its blend of clinically backed ingredients like lion’s mane, gingko biloba, and vitamins B6 and B12 is designed to nourish the brain safely and stimulant-free.

While some users may find the effects fluctuating, the quality assurance from an FDA-regulated facility adds peace of mind.

However, it’s worth noting that long-term benefits and cost could be factors to consider.

Overall, a promising, well-rounded choice for those seeking a natural cognitive boost.

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Neuriva

NEURIVA Ultra Decaffeinated Clinically Tested Nootropic Brain Supplement for Mental Alertness, Memory, Focus & Concentration, Cognivive, Neurofactor, Phosphatidylserine, Vitamins B6 B12, 60 Capsules
Highlights
Improves focus quickly
Caffeine-free formula
Supports memory retention

Neuriva Ultra stands out for its clinically tested, naturally sourced ingredients that target BDNF levels — a game-changer for brain health.

The inclusion of Neurofactor from coffee cherries boosts neuroplasticity, supporting memory and learning, while CogniviveTM delivers a caffeine-free Mental Alertness boost.

The B-vitamins (B6, B12, folic acid) help keep your brain firing on all cylinders.

Although the large capsules might be a bit cumbersome, the rapid focus improvement and plant-based, gluten-free formula make it a top contender.

Just watch for potential gastrointestinal upset and consider the higher price tag, but overall, it’s a smart supplement for mental boost seekers.

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Swanson Brainpower Bdnf Supplements

Swanson Pure Brainpower Brain Health Cognitive Memory Focus Support Brain-Derived Neurotrophic Factor (BDNF) Herbal Supplement (Ginkgo Biloba, Bacopa Monnieri) 60 Veggie Capsules (Veg Caps) Vegan
Highlights
Supports cognitive function
Contains clinically-studied botanicals
Natural, science-backed ingredients

Swanson Pure Science Herbals Pure Brainpower delivers a natural blend of botanicals that truly support neurotransmitter function, focus, and memory.

Its clinically-studied herbs back the science, giving us confidence in its potential.

While results might take a few weeks to show up and consistent use is key, the clean ingredient profile and evidence-backed formulation make it a trustworthy choice.

Perfect for those wanting a natural, science-supported boost to brain health, this supplement is a solid addition to your cognitive support regimen.

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Price history for Swanson Brainpower on Amazon

HEALTH DIRECT AminoMind

HEALTH DIRECT AminoMind - Nootropic Collagen Supplement for Brain Health and BDNF - Pro-Hyp & Hyp-Gly Dipeptides, Coffeeberry Antioxidants - Passionfruit Guava - 14 Fl Oz (28 Servings)
Highlights
Enhances brain function
Supports mood and blood flow
Allergen-free ingredients

AminoMind’s innovative blend of CollaBrain collagen dipeptides and Coffeeberry antioxidants packs a punch for boosting brain function, memory, and focus.

The inclusion of L-Citrulline and L-Tryptophan means improved blood flow and mood support, making it a well-rounded choice for cognitive resilience.

Plus, its allergen-free, all-natural ingredients ensure you’re fueling your brain clean.

While the taste can be a bit robust and the bottle cap has had some leaks, its science-backed formulation and positive early reviews make it a compelling pick for anyone serious about elevating their mental game.

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Price history for HEALTH DIRECT AminoMind on Amazon

Tinc

Tinc 100% Coffee Fruit Extract | Daily Brain Supplement & Booster for Focus, Energy & Alertness | Focus Supplement & BDNF Brain Support (Powder)
Highlights
Natural coffee fruit extract
Clinically proven BDNF boost
Easy to add to routines

Tinc's Daily Brain Boost harnesses the power of natural coffee cherry extract to support cognitive function, making it a clean, effective option for mental clarity.

Its clinically proven ability to stimulate BDNF levels means it might help with brain resilience, development, and connectivity — all crucial for sharp thinking.

Plus, it's incredibly easy to incorporate into your routine—just a tiny pinch in your smoothie or coffee.

While some users find the jar small and average in effectiveness, the natural ingredients and proven science make it a compelling choice for those seeking supportive, plant-based mental agility.

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PPO Lab Brain-Fx Bdnf Supplements

Brain-fx™ Nootropics Brain Energy BDNF Factor Memory & Focus Supplement, Lions Mane Extract, L Theanine, Methyl B12 5MTHF B Complex, Alpha GPC Choline, Bacopa Monnieri, Ginseng, Cordyceps, Huperzine A
Highlights
Clean, Lab-Verified Ingredients
Extended Release Capsules
Supports Brain Health

The Clean Certified & Lab Verified Ingredients give us confidence in its purity and safety, while the Extended Release Capsules ensure a steady supply of nutrients without the crash.

The formula is packed with potent adaptogens, B vitamins, and mushroom extracts, all designed to boost mental clarity, focus, and energy levels.

Although some users report mixed results, the certified organic and non-GMO ingredients make it a great choice for those seeking a premium, holistic brain support supplement.

Keep in mind, the higher price isn't for everyone, but quality comes at a cost!

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Price history for PPO Lab Brain-Fx on Amazon

Guna BDNF

Guna, Inc. - Guna-BDNF (Brain-Derived Neurotrophic Factor) 30ml
Highlights
Supports memory enhancement
Helps reduce stress
Reliable brand

supporting memory enhancement and reducing stress are exactly what you need for a brain boost.

GUNA Biotherapeutics has been around since 2011, so they’ve got a solid track record, and the reliable brand reputation gives us confidence.

Sure, the bitter taste takes some getting used to, and the limited ingredient info leaves a bit to be desired, but the good reviews and decent 4.5-star rating suggest many users find it effective.

If you're after a trusted BDNF supplement to give your cognitive health a little lift, this could be a smart choice.

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Price history for Guna BDNF on Amazon

Gaia Herbs Lion’s Mane

Gaia Herbs Organic Lion’s Mane Mushroom - Brain and Nerve Support Supplement to Help Maintain Neurological Health - with Organic Lion's Mane Mushrooms -120 Vegan Liquid Phyto-Capsules (120-Day Supply)
Highlights
Improves focus and memory
Supports nerve and brain health
All-natural, vegan supplement

Gaia Herbs Lion’s Mane Mushroom not only boosts focus and memory, but it also supports nerve and brain health with a potent 2,500mg of organic, mushroom extract per capsule.

Made in the USA and vegan, it aligns with clean, natural living.

While some users report minor libido effects or mild mental fatigue, results can vary – so patience is key.

Overall, it’s a reliable, all-natural option for those seeking to enhance cognitive function without synthetic ingredients.

It fits seamlessly into any nootropic stack for a clean, plant-based boost.

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Price history for Gaia Herbs Lion’s Mane on Amazon

Genius Lions Mane Bdnf Supplements

Genius Lion’s Mane Supplement Capsules – Organic Full Spectrum Mushrooms for Cognition, Focus & Memory – 1,200mg Per Serving, 120 Count (60 Servings) – Grown in The USA
Highlights
Enhances focus and clarity
Supports overall wellness
Made from high-quality mushroom extract

The Genius Brand’s Lion's Mane supplement supports sharp focus and mental clarity, making it perfect for tackling busy days or intense study sessions.

Rich in antioxidants, it helps fight oxidative stress while promoting overall wellness.

The high-quality mushroom extract ensures you're getting natural benefits without fillers or synthetics.

Just a quick tip — taking 2 capsules with water before a meal is easy to integrate into your routine.

While some may want more long-term data, its versatility and proven benefits make it a solid choice for those seeking mental clarity and wellness support.

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Price history for Genius Lions Mane on Amazon

Neuriva Plus

NEURIVA Plus Brain Supplement for Memory and Focus Clinically Tested Nootropics for Concentration for Mental Clarity, Cognitive Enhancement Vitamins B6, B12, Phosphatidylserine 30 Capsules
Highlights
Clinically tested BDNF boost
High-quality, natural ingredients
Convenient one capsule daily

The clinically tested Neurofactor from coffee cherry extract really seems to give a noticeable boost in brain clarity and focus.

The added B vitamins support sustained energy and mood, which complements the neuro-enhancing effects without any jitters.

Plus, the high-quality, vegetarian, gluten-free ingredients make us feel confident in its purity.

The simplicity of just one capsule at bedtime fits easily into any routine.

While the price has crept up a bit, the proven neuro benefits and premium formulation make this a trusty choice for those looking to enhance their BDNF levels and support overall brain health.

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Price history for Neuriva Plus on Amazon

Pristene

High Definition Brain + Eye Supplement for Memory, Focus & Concentration, Lutein & Zeaxanthin (25mg/5mg) to Protect Your Eyes from Blue Light & Screens, Bilberry Supplement to Support BDNF
Highlights
Enhances brain function
Protects against blue light
Easy to swallow

The high definition ingredients are clinically proven to boost brain and visual function while also providing solid blue light protection.

The patented technology significantly improves absorbability, ensuring your brain and eyes get the nutrients they need right when they need them.

We love the easy-to-swallow capsules and the modern packaging.

While some users remain skeptical about long-term results and more detailed info on BDNF, the overall benefits for digital device users make this a smart choice.

Definitely worth considering if mental clarity and eye safety are your priorities.

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Onnit Bdnf Supplements

ONNIT Alpha Brain Nootropic Brain Supplement for Men & Women | Memory, Mental Clarity & Cognitive Improvement | Focus Capsules with L-Theanine, Vitamin B6 & Phosphatidylserine (30 Count)
Highlights
Supports mental clarity
Caffeine-free formula
Enhances focus

ONNIT Alpha BRAIN provides sharp mental clarity and enhanced focus without the jitters associated with caffeine.

Its unique blend of ingredients like L-Theanine, Alpha GPC, and Phosphatidylserine creates a supportive environment for optimal brain function, making it ideal for high-demand days.

Plus, the caffeine-free formula means you can stay sharp without worrying about crashes or overstimulation.

While it contains some unmeasured maltodextrin and isn’t designed for long-term use, it’s perfect for fleeting mental boosts—whether you're studying, working, or gaming.

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Dr Emil Nutrition

DR. EMIL NUTRITION 2100mg Organic Lions Mane Supplement Capsules - Focus, Mental Clarity & Cognition - Nootropic Lion's Mane Mushroom Supplement with Organic Lions Mane
Highlights
Enhances cognitive function
Supports immune health
High-quality organic extract

Dr.

Emil’s Lion’s Mane Smart Shrooms deliver a potent boost to overall brain health, promoting sharper focus, better memory, and mental clarity.

Plus, they support your immune system with a natural, organic formula crafted from hand-picked, USA-grown mushrooms.

The high-quality extract ensures you get maximum nutrients, and since it's gluten-free and non-GMO, it fits well into a clean, healthy lifestyle.

While results can take some time to fully manifest, the steady improvements are worth the wait.

Overall, a reliable choice for anyone seeking an all-natural cognitive booster.

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