17 Cortisol Blocker Supplements for Stress Support

Discover the top best cortisol blocker supplements to tame stress and boost your mood with our quick, curated guide to feeling balanced and energized.
BrandMy RatingPrice
Thorne
Most Wallet-Friendly
8.6/10
Purify Life
Best for Stress Relief
8.6/10
Totaria
Best for Restful Sleep
8.6/10
Pure Encapsulations
Best for Adrenal Support
9.0/10
Integrative Therapeutics
8.4/10

Best Cortisol Blocker Supplements

Struggling with relentless stress and lingering fatigue? Discover the ultimate allies in your wellness journey — cortisol blocker supplements designed to tame cortisol levels and restore your natural balance. Dive into our curated list of the best options to help you feel more centered, energized, and in control.

Most Wallet-Friendly: Thorne Adrenal Cortex

THORNE Adrenal Cortex - Supplement for Cortisol Management - Support Healthy Adrenal Gland Function, Immune System, Stress Management, Fatigue & Metabolism - 60 Capsules
Highlights
Supports adrenal health
Increases energy levels
Trusted by professionals

As the most wallet-friendly option on our list, it delivers solid adrenal support without breaking the bank.

Designed to help manage cortisol levels, it’s perfect for those battling daily stress and hectic lifestyles.

The unique extract nourishes your adrenal glands, helping to balance stress hormones and boost energy levels.

Plus, with Thorne’s reputable backing—trusted by pro teams and partnered with the Mayo Clinic—you can feel confident in its quality.

While it may need some dosage tweaks for optimal results, it’s a reliable, budget-conscious choice for anyone looking to keep cortisol in check.

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Price history for Thorne Adrenal Cortex on Amazon

Best for Stress Relief: Purify Life

Sugar-Free Rhodiola Rosea Gummies (1500mg/Serving) Adaptogenic Rhodiola Rosea Supplement & Cortisol Blocker for Performance, Stamina, Mood & Motivation - Non-GMO, 60 Vegan Chews, No Capsules or Pills
Highlights
Sugar-Free Formulation
Made in the USA
Adaptogenic Stress Support

These gummies are a delicious way to support stress relief and boost stamina without the sugar crash.

The inclusion of Rhodiola, a time-tested adaptogen, makes this an excellent choice for those looking to naturally modulate cortisol levels.

Plus, being sugar-free and made in the USA ensures quality and a guilt-free experience.

The dense gummy texture might take a little getting used to, and artificial sweeteners are a minor downside, but the overall benefits far outweigh these small quirks.

If you're after a convenient, natural stress supporter, these gummies deserve a spot in your routine.

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Price history for Purify Life on Amazon

Best for Restful Sleep: Totaria Cortisol Support

Cortisol Supplement with Ashwagandha,Magnesium,Rhodiola Rosea,L Theanine,Hormone Balance for Women 120 Vegan Capsules (Pack of 1)
Highlights
Supports cortisol regulation
Reduces hot flashes
Easy to swallow

We love how it harnesses high-quality Ashwagandha and Magnesium Glycinate to support cortisol regulation naturally.

The 20:1 Ashwagandha extract offers a potent adaptogenic boost, helping to restore adrenal balance and promote relaxation.

Plus, the inclusion of Phosphatidylserine adds a cognitive support element, making it more than just a cortisol blocker.

While some users might find the pill size a bit large or need some dosage patience, we appreciate its Made in the USA quality standards.

Overall, a well-rounded supplement for those aiming for hormonal harmony and stress relief.

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Price history for Totaria Cortisol Support on Amazon

Best for Adrenal Support: Pure Encapsulations Adrenal

Pure Encapsulations Adrenal | Supplement to Support Healthy Cortisol Levels, Fatigue, Stress Moderation, and Adrenal Gland Function* | 60 Capsules
Highlights
Supports adrenal health
Premium quality ingredients
Helps manage stress

Pure Encapsulations' Adrenal support is specifically designed with adrenal health in mind, making it a top choice for those looking to keep cortisol in check while bolstering energy levels.

The premium ingredients are a big plus, sourced from trusted suppliers and carefully tested for potency and purity.

We appreciated its clean formulation—free from common allergens and artificial ingredients.

While some users might experience initial jitters, overall, it provides comprehensive support for adrenal function and stress management.

Just a heads-up: long-term effects are still being studied, so use with mindful expectations.

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Price history for Pure Encapsulations Adrenal on Amazon

Integrative Therapeutics Cortisol Manager

Integrative Therapeutics - Cortisol Manager - Supplement with Ashwagandha and L-Theanine - Supports Relaxation & Calm* - 30 Tablets
Highlights
Supports Stress Balance
Promotes Restful Sleep
Trusted Quality Brand

Integrative Therapeutics' Cortisol Manager is a reliable choice for those seeking balanced cortisol levels and better stress response.

The blend of Ashwagandha and L-Theanine works seamlessly to promote calmness and relaxation, making it easier to unwind after a hectic day.

Plus, it supports restful sleep, which is a huge bonus.

While some users report vivid dreams or feeling over-sedated, the overall quality and trusted brand reputation make this a solid pick.

If stress reduction with added sleep support is your goal, this supplement could be just what you need.

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Price history for Integrative Therapeutics Cortisol Manager on Amazon

LES Labs Cortisol Health

LES Labs Cortisol Health – Stress Relief, Balanced Cortisol Response, Relaxation & Deep Sleep – Phosphatidylserine, Magnesium, Magnolia Bark, Rhodiola Rosea & Ashwagandha – Non-GMO – 60 Capsules
Highlights
Supports restful sleep
Natural calming ingredients
Balances cortisol levels

Cortisol Health by LES Labs delivers on its promise to promote a balanced cortisol response and support restful sleep with its drug-free, natural ingredients.

The formula combines phosphatidylserine, magnesium, ashwagandha, magnolia, and rhodiola root extract, all known for their calming and stress-relieving benefits.

Many users report feeling more relaxed during stressful days and enjoying deeper, more restorative sleep at night.

While some might experience slight oversleeping or find the price a bit steep, the quality and effectiveness make it a solid choice for anyone looking to keep cortisol levels in check naturally.

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Price history for LES Labs Cortisol Health on Amazon

NutraHarmony Cortisol Support Cortisol Blocker Supplements

Cortisol Supplement for Women - Natural Based Hormone Balance - Ashwagandha | Rhodiola | Holy Basil | L-Theanine - Mood, Focus & Sleep Support - Made in USA - Vegan, Non-GMO - 60 Capsules for 2 Month
Highlights
Helps reduce stress
Improves sleep quality
Contains natural ingredients

The Cortisol Support Complex delivers on its promise to balance cortisol levels naturally.

The blend of herbs, vitamins, and minerals creates a harmonious formula that can help reduce stress and improve sleep quality.

While a few users report bloating or occasional eye twitching, most find it a worthy addition to their daily wellness routine.

Made in the USA, this supplement aligns with high standards of quality and efficacy.

If you're seeking a natural way to keep cortisol in check and boost resilience, this may be a smart choice—just keep an eye on how your body responds.

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Price history for NutraHarmony Cortisol Support on Amazon

AMENQ Cortisol Drops

Cortisol Supplement Liquid Drops, Cortisol Reducer w. Magnesium Glycinate, Ksm-66 Ashwagandha, L-Theanine, Liquid Magnesium Cortisol Drink Mix for Cortisol & Hormone Balanced, Relax, Calm, Strawberry
Highlights
Effective sleep aid
Good taste and value
Supports relaxation

The Strawberry-flavored cortisol liquid is not only delicious but also packs a punch with a potent blend of ingredients designed to boost your relaxation and hormone balance.

Its comprehensive formula combines highly bioavailable magnesium with adaptogens like Ashwagandha and L-Theanine, promoting a calm, balanced cortisol response while supporting restful sleep.

The liquid form ensures quick absorption, making it an excellent choice for those who need fast relief.

While the dosing instructions might be a tad confusing and some users report minor next-day drowsiness, its overall effectiveness and clean ingredients earn it a solid spot in our top picks for cortisol support.

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Price history for AMENQ Cortisol Drops on Amazon

BBEEAAUU

Cortisol Supplements for Women & Men - 10-in-1 Cortisol Reducer Manager Detox with Ashwagandha, Magnesium - Lower High Cortisol Levels, Relaxation & Night Support, Non-GMO, 120 Capsules
Highlights
Effective stress reduction
Natural, high-quality ingredients
Long-lasting 60-day supply

The BBEEAAUU Cortisol Balance Capsules pack a powerful punch with their premium 10-in-1 formula, thoughtfully crafted to support cortisol detox naturally.

With a blend of magnesium glycinate, Ashwagandha, Rhodiola, and other herbal extracts, it offers targeted stress reduction while promoting relaxation.

The capsules are vegetarian-friendly and free from artificial additives, making it a clean choice for health-conscious users.

Although it might take a bit of patience to see results, the long-lasting 60-day supply adds great value.

Overall, this supplement is an excellent option for those seeking a natural, effective stress support without any fuss.

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Price history for BBEEAAUU on Amazon

Dr. Matthew Cortisol Reducer Cortisol Blocker Supplements

Dr. Matthew Cortisol Reducer Supplement for Women. Adrenal Support with Ashwagandha, Rhodiola & Ginseng – A Detox Cocktail to Lower Cortisol & Aid Relaxation, Calm and Restful Sleep
Highlights
Effective stress reduction
Improves sleep quality
Natural and non-GMO

The blend of adaptogens like ashwagandha, rhodiola rosea, and panax ginseng offers a powerful synergy to naturally reduce stress and support adrenal health.

Users report better sleep quality and a calmer mood, thanks to the supplement’s focus on cortisol regulation.

Plus, it’s 100% plant-based, non-GMO, and free from fillers—making it both safe and effective.

Keep in mind, some have noted strange dreams or slight variations in potency, but overall, this formula provides a well-rounded approach to stress relief and energy support.

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Price history for Dr. Matthew Cortisol Reducer on Amazon

Nugenix

Nugenix Cortisol Control - Cortisol Manager and Adrenal Support Supplement for Men, 60 Capsules
Highlights
Supports adrenal health
Reduces stress and tension
No artificial fillers

Nugenix Cortisol Control employs a powerful blend of six carefully selected ingredients, including patented Sensoril and Relora, to help keep cortisol in check and support your body's stress resilience.

Many users report feeling more energized, with a clearer mood and less tension—ideal for those overwhelmed by daily stressors.

Plus, it's manufactured under strict FDA guidelines and free from gluten, soy, GMOs, and artificial fillers.

While results can vary, this supplement offers a solid, science-backed option for maintaining adrenal balance and combating stress naturally.

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Price history for Nugenix on Amazon

Healths Harmony Adrenal Support

Adrenal System Support & Cortisol Manager (2 Month Supply) Powerful Ashwagandha & L-Tyrosine Fatigue Supplement - Maintain Balanced Cortisol Levels, Health, & Stress Relief - Non-GMO - 60 Capsules
Highlights
Effective stress reduction
Improves sleep quality
Affordable for quantity

Healths Harmony's Adrenal System Support is a thoughtfully formulated supplement designed to keep your cortisol levels in check.

It combines key ingredients like Vitamin C, B6, and adaptogens such as Rhodiola and Holy Basil to help you stay calm under pressure.

We appreciate the US-made GMP standards ensuring high-quality, clean ingredients without fillers.

While some users may experience mild stomach discomfort or headaches, results can take a bit of time.

Overall, if you’re looking for a reliable, natural way to manage occasional stress, this supplement is a worthy contender to help you keep your stress in check.

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Price history for Healths Harmony Adrenal Support on Amazon

MABEFY Cortisol Supplement Cortisol Blocker Supplements

Cortisol Supplement - 10 in 1 Cortisol Manager with Magnesium, Ashwagandha, L-Theanine, Cortisol Health & Stress Relief, Lower Cortisol for Women - 60 Vegetarian Capsules
Highlights
Natural, Vegan Ingredients
Supports Stress Reduction
Enhances Relaxation & Sleep

Cortisoothe combines a thoughtful blend of adaptogens like Ashwagandha, Rhodiola, and St.

John's Wort, which work together to support your body's natural cortisol regulation.

The inclusion of Phosphatidylserine enhances brain function, helping you stay sharp even during stressful days.

Plus, the added vitamins C and D3 bolster your overall health.

This supplement is a great daily pick-me-up for those looking to manage stress more naturally.

And as a bonus, it’s vegan and free from common allergens, making it a wholesome choice for broad lifestyles—a balanced, all-natural approach to keeping cortisol in check.

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Price history for MABEFY Cortisol Supplement on Amazon

Lukaree Cortisol Support

10-in-1 Cortisol Supplements with Magnesium, Ashwagandha, Chamomile, L-Theanine, Phosphatidylserine, St. John's Wort, Rhodiola, Vitamin C & D3, for Women Men, 120 Vegan Capsules for 2 Month, Non-GMO
Highlights
Natural, high-quality ingredients
Long-lasting 60-day supply
Supports stress and sleep

Lukaree’s cortisol supplement boasts a powerful blend of 10 natural ingredients, from adaptogens like ashwagandha and rhodiola to calming chamomile and L-theanine, all aimed at supporting your stress management and sleep quality.

With a generous 60-day supply and vegan capsules, it’s easy to incorporate into your daily routine.

The premium, non-GMO ingredients give us confidence in its quality.

While it offers broad stress support, it may not target cortisol specifically for everyone, but overall, it’s a solid choice for holistic wellness.

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Price history for Lukaree Cortisol Support on Amazon

Luma Nutrition

Luma Nutrition Cortisol Supplement - Cortisol Manager - Ashwagandha + L-Theanine - Cortisol Supplements for Women - 60 Capsules
Highlights
Calms stress effectively
Improves sleep quality
Third-party tested

Luma Nutrition's Cortisol Supplement hits the sweet spot for stress relief, blending powerful adaptogens like ashwagandha with calming L-theanine to deliver a holistic approach.

It helps reduce cortisol levels, making you feel more relaxed, while also sharpening mental clarity and focus.

Plus, with better sleep quality and balanced mood, it supports your whole well-being.

We appreciate the third-party testing and USA manufacturing, ensuring high quality and purity.

While natural ingredients can vary and individual sensitivity may occur, this supplement offers a reliable, veteran-owned option to keep stress at bay and boost your daily performance.

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Price history for Luma Nutrition on Amazon

DLNIA Cortisol Blocker Supplements

Super Calm Cortisol Supplement with Magnesium Glycinate, Ashwagandha, L-Theanine, Phosphatidylserine, Ginkgo Biloba & Lions Mane for Calm, Focus, Mental Clarity, Relaxation, Sleep, Energy
Highlights
Supports stress reduction
Enhances sleep quality
Natural, pure ingredients

DLNIA’s cortisol detox magnesium pills are a holistic powerhouse.

The blend of magnesium glycinate, Ashwagandha, and L-Theanine works synergistically to promote deep relaxation and support your body’s natural stress response.

The added adaptogens like Holy Basil and Rhodiola Rosea help curb cortisol spikes, making it easier to handle daily pressures.

We love that it’s made from pure, ethically sourced ingredients—no gimmicks here.

While results may take a bit of time to show, the gradual, natural approach makes this a solid addition to anyone’s stress relief routine.

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Price history for DLNIA on Amazon

VitaMonk CortiTrax

VitaMonk CortiTrax Natural Cortisol Blocker - Doctor Formulated Cortisol Manager, Cortisol Support & Cortisol Reducer (Already Within Normal Ranges)- 60 Capsule Cortisol Supplement
Highlights
Supports healthy cortisol levels
Natural stress relief ingredients
Enhanced sleep and calm

CortiTrax harnesses a potent blend of natural adaptogens like Ashwagandha, Rhodiola Rosea, Magnolia, and Holy Basil to support a healthy stress response without overstimulating your system.

It’s designed to help maintain normal cortisol levels during stressful moments, supporting restful sleep and boosting daytime energy.

The ingredients are of high quality, and we appreciate the strict adherence to safety standards.

While some users might find they need to use it consistently over time to notice significant benefits, its naturally derived formula makes it a safe bet for those aiming to manage stress holistically.

Be sure to also check out the best ursolic acid supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for VitaMonk CortiTrax on Amazon

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