15 Best Magnesium Supplements for MTHFR Support

Discover the best magnesium for MTHFR to boost your health effortlessly. Find top-rated, trusted options in a quick, clear guide tailored for you.
BrandMy RatingPrice
Qunol
Top Affordable Choice
9.2/10
Triquetra Health
Best for MTHFR Support
9.0/10
Double Wood Supplements
Best for Nervous System Health
9.2/10
Life Extension
Best for Cognitive Function
9.0/10
Bioemblem
9.2/10

Best Magnesium for Mthfr

Struggling to find the perfect magnesium supplement that caters to mthfr needs? You're in the right place—here, we unravel the best magnesium options that can support your unique genetic makeup with ease and confidence. Get ready to discover smart, targeted solutions for optimizing your health journey.

Top Affordable Choice: Qunol Magnesium

Qunol Magnesium Capsules 420mg, 100% DV, High Absorption Magnesium Supplement, Extra Strength, Bone and Muscle Health Supplement, 180 Count
Highlights
High absorption formula
Supports nerve and muscle
No artificial ingredients

Qunol Magnesium Capsules deliver extra strength, high absorption in a budget-friendly package—making it a top pick for those with MTHFR concerns.

The 420 mg dose covers 100% of your daily needs, supporting nerve, bone, and muscle health with ease.

Plus, they're free from artificial flavors and gluten, perfect for sensitive systems.

While the label suggests a double dose and the price is slightly premium, the bioavailability and quality make it worth considering.

Overall, if you're after a reliable, fast-absorbing magnesium, this one truly stands out.

Be sure to also check out the best magnesium threonate gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for Qunol Magnesium on Amazon

Best for MTHFR Support: Triquetra Health Methyl Folate & B12

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
Highlights
Immediate absorption
Supports methylation
Good taste

The bioactive L-Methylfolate in this formula is immediately absorbed, making it a great choice for quick methylation support—no waiting around for breakdown.

The addition of Methyl B12 makes it a powerhouse, ensuring that your methylation pathways stay fully supported, which is especially important for those with MTHFR gene variations.

Plus, the sublingual cherry flavor makes taking it a bit more enjoyable (even if it’s not a candy).

While the taste may not be everyone’s favorite, the immediate absorption and targeted support make this a top contender for MTHFR support.

Be sure to also check out the best magnesium citrate gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for Triquetra Health Methyl Folate & B12 on Amazon

Best for Nervous System Health: Double Wood Magnesium L Threonate

Magnesium L Threonate Capsules (Magtein) – High Absorption Supplement – Bioavailable Form for Sleep and Cognitive Function Support – 2,000 mg – 100 Capsules
Highlights
Supports brain magnesium levels
Clinically shown cognitive benefits
Highly bioavailable form

Magtein Magnesium L-Threonate is the standout when it comes to supporting brain magnesium levels.

It’s the only form clinically proven to boost magnesium in the brain, which makes it ideal for cognitive health and memory support—perfect for those with MTHFR concerns.

Plus, its high bioavailability ensures excellent absorption.

While it’s on the pricier side and has limited flavor options, its scientifically backed benefits for nervous system health truly set it apart.

If brain support is your priority, this supplement might just be your new best friend.

Be sure to also check out the best magnesium spray for muscle pain for more options! Also, here is the price history so you know exactly when to buy!

Price history for Double Wood Magnesium L Threonate on Amazon

Best for Cognitive Function: Life Extension Neuro-Mag

Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules
Highlights
Enhances cognitive function
Supports short-term memory
High-quality, non-GMO ingredients

Neuro-Mag Magnesium L-Threonate is specifically formulated to boost your brainpower.

Its unique form of magnesium is backed by clinical studies, showing real results in quick thinking and short-term memory support.

We love that it's made from high-quality, non-GMO ingredients, ensuring purity and potency.

While it does come with a price tag, it’s a small investment for enhanced cognitive clarity.

Perfect for anyone seeking to sharpen their mental edge, Neuro-Mag truly lives up to its reputation as the best for cognitive function.

Be sure to also check out the best magnesium and vitamin d cream for more options! Also, here is the price history so you know exactly when to buy!

Price history for Life Extension Neuro-Mag on Amazon

BioEmblem Magnesium Complex

BioEmblem Triple Magnesium Complex | 300mg of Magnesium Glycinate, Malate, & Citrate for Muscles, Nerves, & Energy | High Absorption | Vegan, Non-GMO | 90 Capsules
Highlights
Maximum absorption formula
Supports nerve health
Third-party tested quality

BioEmblem's Triple Magnesium Complex offers a powerful blend of 300mg of Glycinate, Malate, and Citrate—each chosen for maximum absorption and bioavailability.

This means you're getting the nutrients you need without stomach upset.

The magnesium glycinate is particularly great for supporting nerve and muscle health, while malate boosts energy production.

Made in the USA with third-party testing, it guarantees quality and purity.

Although it comes at a higher price and may require multiple pills to reach your ideal dose, it’s a reliable option, especially if absorption is top priority.

Be sure to also check out the best lithium orotate for more options! Also, here is the price history so you know exactly when to buy!

Price history for BioEmblem Magnesium Complex on Amazon

Thorne Magnesium CitraMate

THORNE Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
Highlights
High-quality, third-party tested
Supports energy and heart health
Trusted by sports teams

Thorne’s Magnesium Citrate stands out for its high-quality, third-party tested purity, ensuring you get exactly what’s on the label.

It’s a favorite among professional athletes and health practitioners alike, thanks to its support for energy, muscle function, and heart health.

Although it’s a bit on the pricier side, the trusted brand and proven efficacy make it worth considering if you want reliable magnesium support tailored for MTHFR concerns.

Keep in mind, it may not deliver a strong relaxant effect, but for overall wellness and kidney support, it’s a solid choice.

Be sure to also check out the best vitamins for traveling for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne Magnesium CitraMate on Amazon

10X Health 5 MTHF Magnesium for Mthfr

10X Health 5 MTHF Supplement - Methylated Multivitamin with Methylfolate & Magnesium for Brain, Heart Health, DNA & Neurotransmitter Synthesis - Bioavailable 5-MTHF Supplement - 60 Capsules
Highlights
High bioavailability
Mood and focus boost
Supports DNA health

The 10X 5 MTHF supplement offers boosted bioavailability with its 5-MTHF form, making absorption a breeze—no more worries about synthetic folic acid not doing its job.

It’s not just about methylfolate; it also supports mental clarity, mood stability, and overall brain health by promoting neurotransmitter production.

Plus, it backs cardiovascular health and DNA synthesis, which is essential for cellular longevity.

The capsules are straightforward to incorporate into your routine and come in a generous 2-month supply.

While the price leans higher, the quality and efficacy make it a top choice for those with MTHFR concerns.

Be sure to also check out the best potassium gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for 10X Health 5 MTHF on Amazon

BiOptimizers Magnesium Breakthrough

Magnesium Breakthrough Supplement 4.0 - Has 7 Forms of Magnesium: Glycinate, Malate, Citrate, and More - Natural Sleep and Brain Supplement - 30 Capsules
Highlights
High absorption rate
Comprehensive magnesium blend
Natural, no additives

BiOptimizers' Magnesium Breakthrough 4.0 offers a comprehensive blend of 7 different magnesium forms, ensuring your body gets exactly what it needs to support everything from muscle function to mood regulation.

The capsules are designed for fast absorption, so you can feel the effects quickly.

Plus, the natural ingredients mean you're avoiding synthetic fillers and harmful additives.

Keep in mind, the capsule size is a bit on the larger side, and some adjustments might be necessary to fit your dosage needs.

Overall, a solid choice for those seeking total magnesium support, especially for MTHFR.

Be sure to also check out the best tonic for men's health for more options! Also, here is the price history so you know exactly when to buy!

Price history for BiOptimizers Magnesium Breakthrough on Amazon

Vitalitown Magnesium Complex

Vitalitown Magnesium Complex Supplement 500mg - Maximized Absorption Chelated Magnesium Glycinate, Malate, Taurate & Citrate - Vegan Non-GMO Magnesium 120 Capsules for Sleep, Muscle, Energy & Heart
Highlights
Enhanced absorption forms
Improves sleep and calm
Small, easy to swallow

The Four Chelated Forms — magnesium glycinate, citrate, taurate, and malate — are chosen specifically for maximum absorption and bioavailability, making it especially suitable for those with MTHFR who need more efficient nutrient uptake.

The 500mg dose is meant to support energy production, muscle recovery, and overall well-being.

Plus, the small, easy-to-swallow capsules make daily supplementation hassle-free.

While the price is on the higher side and capsule count is limited, the quality, purity, and organic certification make it a solid choice for anyone prioritizing top-tier ingredients with minimal additives.

Be sure to also check out the best mct oil for tinctures for more options! Also, here is the price history so you know exactly when to buy!

Price history for Vitalitown Magnesium Complex on Amazon

Thorne Magnesium Bisglycinate Magnesium for Mthfr

Thorne Magnesium Bisglycinate - Powdered Magnesium Formula - Support Restful Sleep, Muscle Relaxation, Heart Health, and Metabolism - NSF Certified for Sport - 60 Servings - 6.5 Oz Tub
Highlights
Supports restful sleep
Highly absorbable form
Gluten-free & clean

Thorne’s Magnesium stands out with its highly absorbable form, ensuring your body actually benefits from every dose.

It’s a trusted name in the supplement world, backed by professional sports teams and recommended by healthcare practitioners alike.

The formula promotes restful sleep and muscle relaxation—perfect for those busy days when unwinding is a must.

Plus, it supports heart health and blood pressure maintenance, making it a well-rounded choice.

While it’s on the pricier side and requires mixing, the quality and performance make it a worthwhile investment for MTHFR folks seeking top-tier magnesium.

Be sure to also check out the best maca for women for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne Magnesium Bisglycinate on Amazon

Integrative Therapeutics Tri-Magnesium

Integrative Therapeutics Tri-Magnesium - Supports Healthy Bones & Teeth* - Supports Cardiovascular & Neurological Function* - Promotes Calm* - 90 Capsules
Highlights
Supports muscle and heart health
Includes citrate, oxide, malate
Gluten-free and vegan

With 300 mg of elemental magnesium per capsule, it offers solid support for your muscles and cardiovascular health.

The blend of citrate, oxide, and malate forms makes absorption more effective, helping to replenish magnesium levels that stress often depletes.

Plus, its vegan, gluten-free formula makes it accessible to many dietary needs.

While the limited reviews leave some questions about universal effectiveness, the high customer rating and the product's ability to promote calmness and relaxation make it a promising choice.

Ideal for those seeking holistic magnesium support in a convenient supplement.

Be sure to also check out the best lithium orotate brands for more options! Also, here is the price history so you know exactly when to buy!

Price history for Integrative Therapeutics Tri-Magnesium on Amazon

Seeking Health Magnesium

Seeking Health Optimal Magnesium - Mineral Supplement Aids Optimal Magnesium Absorption - Bioavailable Forms of Magnesium for Energy, Sleep & Bone Health Support - 150 mg, 90 Capsules
Highlights
Bioavailable magnesium forms
Supports energy and sleep
Gentle on stomach

Optimal Magnesium delivers a potent dose of two well-absorbed forms—malate for energized mornings and lysinate-glycinate for smooth relaxation and GI comfort.

It’s a trusted choice for supporting your energy levels, sleep, mood, and muscle function all in one capsule.

Plus, it’s free from common allergens and additives, making it a safe pick for sensitive stomachs.

While the capsules are a bit large and come in limited quantity, the quality and targeted benefits truly stand out.

For those seeking convenient, bioavailable magnesium that covers many bases, this one’s a solid choice.

Be sure to also check out the best supplement for methylation for more options! Also, here is the price history so you know exactly when to buy!

Price history for Seeking Health Magnesium on Amazon

PD VARS MTHFR Multivitamin Magnesium for Mthfr

Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy, Mood, & Heart | Vitamin B-Complex | 120 Capsules
Highlights
Supports methylation processes
Includes complete B complex
Improves energy and focus

The MTHFR Daily Multivitamin is a powerful ally for anyone with genetic variations affecting methylation.

It’s packed with methylated nutrients like 5-MTHF and B12, ensuring your body absorbs what it needs without the guesswork.

The complete B complex boosts energy and mental clarity, while its mineral blend supports enzymatic functions crucial for detox and overall wellness.

Although the flavor options are limited and price may be on the higher side, the comprehensive formulation makes it a top choice for targeted support.

If you're seeking robust methylation aid, this one’s worth considering.

Be sure to also check out the best acai powder for more options! Also, here is the price history so you know exactly when to buy!

Price history for PD VARS MTHFR Multivitamin on Amazon

Natural Rhythm Triple Calm

Natural Rhythm Triple Calm Magnesium 150 mg - 120 Capsules – Magnesium Complex Compound Supplement with Magnesium Glycinate, Malate, and Taurate. Calming Blend for Promoting Rest and Relaxation.
Highlights
High bioavailability forms
Gentle on stomach
Enhances relaxation

Triple Calm Magnesium excels in combining high-bioavailability forms like magnesium taurate, glycinate, and malate, making absorption a breeze.

The gentle, non-laxative nature means it’s easy on the stomach—no nasty surprises there.

While it’s not the most potent option for sleep, it truly shines as a relaxation and stress reduction support, promoting a sense of calm and balance.

Crafted with top-tier, non-GMO, gluten-free ingredients, it's perfect for those seeking purity alongside effectiveness.

Ideal for restoring your natural rhythm with minimal fuss!

Be sure to also check out the best mushroom matcha for more options! Also, here is the price history so you know exactly when to buy!

Price history for Natural Rhythm Triple Calm on Amazon

Pure TheraPro Rx

Pure TheraPro Rx Optimum Magnesium Lysinate Glycinate & Di-Magnesium Malate, Made in USA | 2 Month Supply | Chelated Magnesium for Maximum Absorption, Supports Bone Health & Energy, Non-GMO
Highlights
High bioavailability chelate
Delayed release for absorption
No artificial extras

Optimum Magnesium’s highly bioavailable chelate ensures maximum absorption without the sluggishness some supplements cause.

The delayed-release EmboCaps mean your body gets a steady stream of magnesium into the small intestine, boosting efficacy and reducing stomach discomfort.

Plus, the formula’s energy-boosting Malic Acid makes it a great choice for daytime use—no drowsiness here!

Manufactured right in the USA with strict quality standards, it’s free from common allergens and artificial junk.

While the price and some capsule issues could be improved, overall, this supplement is a solid pick for those with MTHFR looking to optimize magnesium intake.

Be sure to also check out the best soursop bitters for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure TheraPro Rx on Amazon

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