13 Top Niacin Extended Release 500 Mg Supplements Reviewed

Discover the best niacin extended release 500 mg for smooth vitality and balanced energy, curated for clarity and quick picks in the supplements world.
BrandMy RatingPrice
21st Century
Top Money-Saving Choice
9.2/10
Nature's Bounty
Best for Flushing Sensitivity
9.4/10
Endurance Products
Best for Steady Energy Support
9.2/10
21st Century
Best for Gentle Absorption
8.8/10
Now Foods
8.6/10

Best Niacin Extended Release 500 Mg

Looking to elevate your wellness routine with a reliable dose of niacin? In the bustling world of supplements, finding the best extended-release 500 mg options can feel overwhelming — but fear not. We’ve narrowed down the top contenders to help you make a quick, informed choice so you can enjoy smoother circulation and vibrant energy with ease.

Top Money-Saving Choice: 21st Century Niacinamide

21st Century Niacinamide 500mg Prolonged Release Tablets, 110-Count, Vitamin B Complex Supplement for Energy, Heart & Nervous System Support, Non-GMO, Vegan-Friendly, Adult Daily Vitamins
Highlights
Extended release formula
Good for sleep support
Low flushing effect

As our "Top Money-Saving Choice," it offers an excellent prolonged-release formula at a budget-friendly price.

The extended-release technology ensures a slow, steady delivery of niacin, promoting sustained energy metabolism and potentially better sleep support—minus the typical flushing sensation.

Plus, it’s free from artificial additives, gluten, and is vegan-friendly, making it a clean choice.

Made by 21st Century, a trusted name with over 30 years in quality manufacturing, this supplement provides top value without sacrificing purity or effectiveness.

It’s a smart, cost-effective pick for those wanting reliable extended-release niacin.

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Price history for 21st Century Niacinamide on Amazon

Best for Flushing Sensitivity: Nature's Bounty Niacin

Nature's Bounty Niacin 500mg Flush Free, Cellular Energy Support, Supports Nervous System Health, 120 Capsules
Highlights
Flush free formula
Supports nervous system
High customer satisfaction

This Niacin offers a flush-free experience thanks to its unique inositol hexanicotinate formulation.

It effectively delivers cellular energy support while minimizing skin flushing, which is a game-changer for sensitive users.

Plus, it supports your nervous system health, making it a well-rounded choice for daily wellness.

Backed by over 50 years of scientific research from Nature's Bounty, it guarantees quality and reliability.

While it may not be the cheapest, its high customer satisfaction and gentle profile make it a top contender for those seeking a safe, effective niacin supplement without the flush.

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Price history for Nature's Bounty Niacin on Amazon

Best for Steady Energy Support: Endurance Products

ENDUR-ACIN, Extended Release Niacin for Optimal Absorption & Low-Flush Vitamin B3 Niacin 500mg, Premium Niacin Supplement Made in USA, 200 Tablets
Highlights
Gradual Extended-Release
Easy to Swallow
Made in USA

Endur-Acin truly lives up to its reputation as the best for steady energy support.

The gradual extended-release formula ensures your energy levels stay consistent without the pesky spikes or crashes often associated with other supplements.

The easy-to-swallow tablets make daily intake hassle-free, while the gentle absorption helps maintain optimal niacin levels throughout the day.

Plus, being made right here in the USA by a family-owned business gives us confidence in its quality and safety.

If smooth, sustained energy is what you’re after, this one’s a solid choice!

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Price history for Endurance Products on Amazon

Best for Gentle Absorption: 21st Century Niacin 500mg

21st Century Niacin 500 mg Prolonged Release Tablets, 100 Count (27474)
Highlights
Affordable price
Prolonged-release
No flushing (sometimes)

Our team chose it as "Best for Gentle Absorption" *due to its prolonged-release, minimal-flush formulation, making it ideal for those with sensitive stomachs or skin.

While it’s designed to reduce flushing, some users still experience occasional redness, so keep that in mind.

Plus, it’s free of added sugar, salt, yeasts, preservatives, and artificial colors, aligning with clean supplement standards.

Just a heads-up: heat and sunlight might damage the packaging, so timely delivery and careful storage are key.

Overall, a solid, budget-friendly choice for extended niacin support.*

Be sure to also check out the best life extension supplements for more options! Also, here is the price history so you know exactly when to buy!

Price history for 21st Century Niacin 500mg on Amazon

NOW Foods Niacin

NOW Foods Supplements, Niacin (Vitamin B-3) 500 mg, Sustained Release, Nutritional Health, 250 Tablets
Highlights
Minimized flushing symptoms
Longstanding USA brand
Effective for cholesterol

The sustained release formula does a solid job of minimizing flushing and itching, common side effects with niacin — always a win.

Plus, it’s crafted by a longstanding USA-based family-owned company, which speaks volumes about quality and trust.

The recommended daily dose with a meal makes it easy to incorporate into your routine, and it’s effective for cholesterol support too.

Just keep in mind, some users still experience mild flushing, especially at higher doses, so gradual dosing is key for comfort.

Overall, a reliable choice for those seeking a gentle, extended-release niacin supplement.

Be sure to also check out the best amino energy flavors for more options! Also, here is the price history so you know exactly when to buy!

Price history for NOW Foods Niacin on Amazon

Doctor's Best Niacin

Doctors Best Sustained-Release Niacin with niaXtend, Supports Heart Health, Non-GMO, Gluten Free, Vegan 120 Tablets
Highlights
Effective for flushing relief
Supports metabolism health
No flushing at all

Real Niacin provides a smooth, extended-release form that ensures you get all the benefits of vitamin B3 without the uncomfortable skin flushing that can sometimes be a hassle with other formulations.

It supports those essential enzymatic reactions involved in metabolism and energy production, making it a solid choice for everyday health.

Plus, since it’s designed to release over 8 hours, you can enjoy its benefits without frequent dosing.

Just a heads-up—initial flushing may still occur, and the large tablets might take some getting used to.

Overall, a hassle-free option for sustained support.

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Price history for Doctor's Best Niacin on Amazon

Niacinex Niacin Extended Release 500 Mg

Niacin 500mg Extended Time Release Tablets Minimal to No-Flush, Vitamin B3 Supplement - Cholesterol Balance, Nicotinic Acid - Vegan, cGMP, made in The USA (1 Pack)
Highlights
Minimal flush experience
Supports heart health
Third-party verified

Niacinex’s extended-release 500mg formula ensures a smooth, no-flush experience while delivering all the heart-healthy benefits of vitamin B3.

The slow and steady release over 6-8 hours maximizes absorption without the uncomfortable skin tingling or redness common with other forms.

Plus, it's crafted with plant-based ingredients and manufactured in the USA in a cGMP facility, assuring quality and transparency with a third-party certificate of analysis.

While it may come at a slightly higher price point, its effectiveness, ease of use, and satisfaction guarantee make it a solid choice for daily support.

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Price history for Niacinex on Amazon

Nutricost Niacin 500mg

Nutricost Niacin (Vitamin B3) 500mg, 240 Capsules - with Flushing, Non-GMO, Gluten Free
Highlights
Potent 500mg dose
Non-GMO & gluten-free
Third-party tested

The potent 500mg dose delivers a powerful boost, perfect for those who need a serious niacin punch.

It's non-GMO, gluten-free, and third-party tested, so quality is assured.

However, be prepared for the classic niacin flush—a tingling, redness that can be intense for some.

We advise taking it with food or starting with a smaller dose if you're new to extended-release supplements.

While it may cause dizziness or skin welts in sensitive users, for many, this product hits the mark with its effectiveness and purity.

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Price history for Nutricost Niacin 500mg on Amazon

Nature's Blend

Nature's Blend Niacin Timed Release 500 mg 500 mg 300 Tabs
Highlights
Reduces flushing
Supports heart health
Easy to swallow

Nature's Blend Niacin Timed Release offers a clever way to enjoy all the benefits of niacin without the unwelcome flush, thanks to its gradual release formula.

It’s especially noted for supporting cardiovascular health by promoting healthy lipid levels, making it a smart choice for those prioritizing heart wellness.

Plus, it’s easy to swallow, which is a big plus for many users.

However, keep in mind that some still experience flushing, and there’s the allergen concern with abalone.

Overall, it's a reliable option that balances efficacy with comfort.

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Price history for Nature's Blend on Amazon

Designs for Health Niacin 500mg Niacin Extended Release 500 Mg

Designs for Health Niacin 500mg - Niacin CRT Vitamin B3 (Nicotinic Acid), Controlled Slow Release Tablets to Help Minimize Flush - Non-GMO, Gluten Free Supplement (60 Tablets)
Highlights
Supports Healthy Blood Lipids
Slow Release, No Flushing
Trusted Practitioner Brand

Niacin CRT offers a therapeutic, controlled-release of 500 mg, providing a steady stream of niacin that minimizes the notorious flush — a common drawback with instant-release variants.

Its slow-release system ensures your blood levels stay consistent for 6-8 hours, supporting healthy blood lipids and circulation without sudden surges.

Plus, as a non-GMO, gluten-free, vegetarian option, it meets high standards we appreciate.

While some users might experience mild flushing or allergies, the overall trusted quality from Designs for Health makes it a top contender for those seeking consistent, professional-grade support in their supplement routine.

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Price history for Designs for Health Niacin 500mg on Amazon

Vital Nutrients Niacin 500mg

Vital Nutrients Niacin 500mg | Timed-Release Niacin Supplement for Men & Women | Vitamin B3 Supports Heart Health and Protein & Fat Metabolism | Gluten, Dairy, Soy Free | Non-GMO | 90 Tablets
Highlights
Supports heart health
Pure, clean-label formula
Trusted by professionals

Vital Nutrients Niacin Extended Release 500 mg delivers a reliable, slow-release formula that minimizes flushing while supporting healthy circulation and heart health.

The clean, vegan, non-GMO ingredients mean you're getting a pure supplement free from common allergens and artificial additives.

Plus, with rigorous third-party testing, you can trust the label's accuracy.

While some users might experience minor side effects like flushing or bruising, the overall quality and professional backing make this a solid choice for those seeking effective, safe support for cardiovascular wellness and energy metabolism.

Be sure to also check out the best allergen free multivitamin for more options! Also, here is the price history so you know exactly when to buy!

Price history for Vital Nutrients Niacin 500mg on Amazon

Endurance Products B3 Niacin

B3 Plain Niacin - 500mg Immediate Release Vitamin B-3 with Flush - Nicotinic Acid 100 Tablets - Non-GMO, Vegan, Gluten Free
Highlights
Gradual release formula
Supports heart health
Vegan & allergen-free

Its gradual release formula makes it a standout choice for those wanting to avoid the usual niacin flush.

The 500mg of immediate-release niacin is cleverly embedded in a vegetable-based wax matrix, slowly releasing over about an hour—helping support heart health and cholesterol balance effectively.

Plus, it's vegan, allergen-free, and manufactured in the USA at an FDA-registered facility, which adds peace of mind.

While individual tolerance varies and some may still experience flushing or skin itching, this supplement offers a well-rounded, safe option for those seeking targeted B3 benefits without common allergens.

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Price history for Endurance Products B3 Niacin on Amazon

Dr Berg Niacin Niacin Extended Release 500 Mg

Dr. Berg Niacin 500mg with Flushing for Heart Health & Energy Support* - 100-Day Supply Vitamin B3 Niacin from Dr. Berg Recommended Nicotinic Acid - 100 Capsules
Highlights
Supports cardiovascular health
100-day supply included
Effective energy boost

Dr.

Berg's Niacin Extended Release 500 mg delivers a potent dose that supports your cardiovascular health and boosts cellular energy.

The 100-day supply means you can stay consistent without constantly reordering—perfect for busy lifestyles.

While the flushing effect can be a bit intense, taking it with food helps mitigate this.

Plus, it’s designed to protect your cells from oxidative stress, making it a solid choice for those seeking a comprehensive B3 supplement.

Overall, if you're looking for a reliable and long-lasting niacin option, this product deserves a spot on your list.

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Price history for Dr Berg Niacin on Amazon

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