14 Probiotics for Sleep That Boost Rest Naturally

Discover the best probiotics for sleep that gently boost your nightly rest, blending science and nature for a peaceful, rejuvenating sleep experience.
BrandMy RatingPrice
Gut Response
Best Cheap Pick
8.6/10
Solgar
Best for Insomnia Relief
8.0/10
Fr!ska
Best for Relaxation Support
8.4/10
Garden of Life
Best for Immune and Sleep
9.0/10
Peptiva
8.2/10

Best Probiotics for Sleep

In the quest for sweet, restorative slumber, the right probiotics can be your secret weapon. These tiny but mighty microbes not only support gut health but also play a starring role in balancing your sleep cycle and boosting overall tranquility. Dive in to discover the best probiotics for sleep that will have you snoozing soundly in no time.

Best Cheap Pick: Gut Response Sleep Probiotic

Sleep Probiotic for Men & Women, Slows Down Digestive Aging, Supports Sleep and Recovery, Promotes Healthy Gut, Vegan, Gluten Free & Soy Free, 3 Billion CFU, 30 Caplets
Highlights
Supports digestive health
Promotes healthy sleep cycles
Dairy and gluten free

Gut Response Sleep Probiotic earns its spot as the "Best Cheap Pick" thanks to its affordable price and trustworthy formula.

With just 3 billion CFUs and 11 strains, it offers solid support for digestion and sleep without breaking the bank.

Its blend includes melatonin and theanine, which are great for promoting relaxed sleep cycles and reducing bloating.

Plus, it's non-GMO, gluten-free, and dairy-free—making it accessible for most diets.

While it may have fewer CFUs and strains than pricier options, it still delivers a valuable, budget-friendly sleep support boost.

Be sure to also check out the best probiotics for alcohol drinkers for more options! Also, here is the price history so you know exactly when to buy!

Price history for Gut Response Sleep Probiotic on Amazon

Best for Insomnia Relief: Solgar Sleep Support

Solgar Advanced Sleep Support Probiotic with GABA & Melatonin, 30 Vegan Capsules - 30 Billion CFU - 5 Clinically-Studied Strains - Support for Restful Sleep & Recovery - Non-GMO & Vegan, 30 Servings
Highlights
Supports restful sleep
Clinically studied strains
GABA & Melatonin included

Solgar's Advanced Sleep Support Probiotic stands out as best for insomnia relief thanks to its powerful combination of GABA and Melatonin, targeting sleep quality directly.

The inclusion of clinically studied strains like L. paracasei Lpc-37 helps reduce stress and exhaustion, making it ideal for those struggling with restless nights.

Plus, with a solid 30 billion CFU, it offers a convenient dose to promote recovery and restful sleep.

We appreciate its non-GMO, vegan formulation, ensuring peace of mind for health-conscious users.

While effectiveness can vary, it's a reliable choice for supporting your nightly recharge.

Be sure to also check out the best probiotics for dental health for more options! Also, here is the price history so you know exactly when to buy!

Price history for Solgar Sleep Support on Amazon

Best for Relaxation Support: FR!SKA Nightly Reboot

FRISKA Nightly Reboot Enzyme and Probiotics Supplement, Promotes Better Digestion and Sleep, Supports Gut Health for Men and Women, Melatonin, Chamomile, 30 Capsules
Highlights
Supports gut health
Promotes relaxation & sleep
Helps digestion overnight

Nightly Reboot earns our top spot as the "Best for Relaxation Support" because it expertly combines probiotics with calming herbs like Chamomile and Melatonin.

This thoughtful blend not only supports gut health but also promotes ultimate relaxation for a more restful sleep.

The inclusion of digestive enzymes helps ease overnight digestion, reducing bloating and discomfort — common culprits behind restless nights.

With just one capsule at night, it’s a straightforward way to unwind and wake up feeling refreshed. A well-rounded choice for anyone seeking better sleep without sacrificing gut health.

Be sure to also check out the best probiotic for hemorrhoids for more options! Also, here is the price history so you know exactly when to buy!

Price history for FR!SKA Nightly Reboot on Amazon

Best for Immune and Sleep: Garden of Life Calm Daily

Garden of Life Dr Formulated Calm Daily 3-in-1 Complete Probiotics, Prebiotics & Postbiotics with Ashwagandha - PRE + PRO + POSTBIOTIC Supplement for Immune, Digestive & Mood Support - 30 Day Supply
Highlights
Calms nerves effectively
Clinically studied strains
Includes prebiotics & postbiotics

*The Dr.

Formulated Calm WHOLEbiotic stands out as the best for immune and sleep* because it combines 14 clinically studied strains with a powerful mix of prebiotics and postbiotics.

This triple-action formula not only promotes gut health but also helps to calm nerves and reduce stress—thanks to ingredients like Ashwagandha and Blueberry.

Yes, the capsules are on the larger side, but their science-backed ingredients and comprehensive approach make it worth the upgrade for anyone seeking better sleep and overall resilience.

Be sure to also check out the best probiotics for tonsil stones for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life Calm Daily on Amazon

Peptiva

Peptiva 26 Billion CFU Probiotic and Sleep Support - Clinically Validated Multi-Strain Probiotic - Lactobacillus and Bifidobacterium, Melatonin - 30 Count
Highlights
Supports sleep and digestion
Clinically validated strains
Doctor-formulated

Peptiva + Sleep Support combines ultra-potent, clinically validated strains designed by top-tier doctors, including Dr.

David Katz.

It doesn't just promote sleep; it supports overall digestive health, making it a great all-in-one choice.

Plus, many users find relief from intestinal discomfort and a feeling of relaxation within just 30 minutes.

That said, it may take up to 12 weeks to see full benefits, and some users might experience minor digestive discomfort initially.

Overall, it’s a reliable, science-backed option for those seeking a gentle sleep aid with added gut benefits.

Be sure to also check out the best probiotic drops for newborns for more options! Also, here is the price history so you know exactly when to buy!

Price history for Peptiva on Amazon

Garden of Life Probiotics Mood+

Garden of Life Probiotics Mood+ Dr Formulated Acidophilus Probiotic Supplement - Promotes Emotional Well-Being, Relaxation and Digestive Balance - Ashwagandha for Stress Management, 60 Veggie Caps
Highlights
Supports mood and relaxation
Shelf stable & potent
Includes stress-reducing ingredients

The Doctor Formulated Probiotics deliver a powerful 50 billion CFU along with 16 probiotic strains, including clinically studied ones that support mood and relaxation.

The addition of organic Ashwagandha and Alaskan Blueberry makes it a standout for stress management.

It’s shelf-stable and potent even in warm weather, giving peace of mind during shipment.

Plus, it’s third-party certified non-GMO and gluten-free, aligning with health-conscious standards.

While results can vary, many users feel a noticeable calm and improved sleep, making this a solid choice for those seeking natural support.

Be sure to also check out the best probiotic with butyrate for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life Probiotics Mood+ on Amazon

Garden of Life Magnesium Gummies Probiotics for Sleep

Garden of Life - Dr Formulated Magnesium Citrate Supplement with Prebiotics & Probiotics for Stress, Sleep & Recovery - Vegan, Gluten Free, Kosher, Non-GMO, No Added Sugars – 60 Raspberry Gummies
Highlights
Effective for sleep
Pleasant taste
Supports digestion

The **_Garden of Life Dr.

Formulated Magnesium Gummy_** packs a punch when it comes to supporting sleep and relaxation.

Each gummy delivers 100mg of bioavailable Magnesium Citrate, helping to promote a calm, restful night and keep your heart healthy.

The delicious raspberry flavor makes it easy to incorporate into your nightly routine, and the added probiotics boost digestion — a win-win!

While the dense texture might take some time to get used to, the benefits definitely outweigh the slight chewiness.

Overall, it’s a tasty, effective solution for better sleep and overall wellness.

Be sure to also check out the best broccoli supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life Magnesium Gummies on Amazon

Sleepbiotic Pro

Sleepbiotic Pro - Multi-Strain Probiotic Sleep Support - Aid Gut Health & Immune Support - Promote Relaxation & Sleep Quality with Premium Probiotics - Lactobacillus & Bifidobacterium - 40 Billion CFU
Highlights
Supports Sleep & Gut Health
High CFU Count
Contains Relaxation Support

With 40 billion CFUs per serving, it packs a powerful punch for supporting both sleep and gut health.

The delayed-release vegetarian capsules ensure the probiotics make it deep into your gut where they do their best work.

Its focus on relaxation—thanks to key strains like Lactobacillus Acidophilus & Bifidobacterium Longum—is noticeable, helping promote better sleep quality.

While it’s somewhat limited in strain variety and only available in capsule form, it’s a solid, USA-made option backed by a 60-day satisfaction guarantee.

Perfect for those seeking a sleep-friendly probiotic with high CFUs!

Be sure to also check out the best pre-workout for endurance for more options! Also, here is the price history so you know exactly when to buy!

Price history for Sleepbiotic Pro on Amazon

Garden of Life Sleep Well

Garden of Life Organics Sleep Well Rest & Refresh 30 Tablets, Lemon Balm, Green Tea Extract L-Theanine, Valerian Root, Chamomile, Probiotics-Organic Non-GMO Vegan Gluten Free Herbal Supplement
Highlights
Promotes restful sleep
Includes relaxation herbs
Organic, non-GMO ingredients

It really promotes restful sleep, helping you wake up feeling truly refreshed.

The blend of calming herbs like organic lemon balm, valerian, passionflower, and chamomile creates a natural relaxation zone—perfect for winding down.

Plus, it includes L-Theanine from organic green tea, which clinically aids deep relaxation.

The ingredients are all certified organic and Non-GMO, aligning with clean lifestyle choices.

However, the larger pill size might be a hurdle for some, and results can vary from person to person.

Still, it’s a strong choice for quality sleep support.

Be sure to also check out the best broccoli sprout supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life Sleep Well on Amazon

Nature's Bounty Probiotic 10 Probiotics for Sleep

Nature's Bounty Probiotic 10, Ultra Strength Daily Probiotic Supplement, Support for Digestive, Immune and Upper Respiratory Health, 1 Pack, 30 Capsules
Highlights
Supports gut health
Multi-strain formula
20 billion CFU

Ultra Strength Probiotic 10 delivers a solid punch with 20 billion CFUs per capsule, supporting a healthy gut and immune system with its multi-strain diversity.

While it’s not specifically formulated for sleep, maintaining a balanced gut can promote overall relaxation and well-being, which indirectly benefits rest.

The convenient one-per-day capsule makes it easy to incorporate into your routine, backed by over 20 years of research and quality.

If you're looking for a reliable probiotic to enhance your digestive and immune health, this one’s a confident choice—just don’t expect it to be a direct sleep aid.

Be sure to also check out the best tonic for men's health for more options! Also, here is the price history so you know exactly when to buy!

Price history for Nature's Bounty Probiotic 10 on Amazon

NewRhythm Probiotics

NewRhythm Probiotics 50 Billion CFU 20 Strains, 60 Veggie Capsules, Targeted Release Technology, Stomach Acid Resistant, No Need for Refrigeration, Non-GMO, Gluten Free
Highlights
Made in USA
Clinically Proven 50B CFU
Stomach Acid Resistant

NewRhythm 50 Billion Probiotics is made right in the USA, guaranteeing quality and purity.

Its clinically backed formula packs 50 billion CFUs across 20 strains, designed with targeted release technology to ensure the probiotics survive digestive acids and reach your gut effectively.

Plus, it includes organic prebiotics for added digestive support.

The capsules are shelf-stable, so no refrigeration is needed—perfect for busy mornings or travel.

While it could benefit from a broader strain variety, its potent formula and high standards make it a fantastic choice for supporting sleep and overall gut health.

Be sure to also check out the best vitamins for sensitive stomach for more options! Also, here is the price history so you know exactly when to buy!

Price history for NewRhythm Probiotics on Amazon

Dr. Berg 60 Billion Probiotic

Dr. Berg 60 Billion Probiotic Supplement - Supports Occasional Constipation, Diarrhea, Gas & Bloating* - Pre and Probiotics for Digestive Health - 30 Probiotic Capsules
Highlights
High-quality ingredients
Effective gut support
Includes prebiotics and vitamins

The blend of 10 unique probiotic strains paired with a proprietary prebiotic mix crafted by Dr.

Berg ensures your gut gets a comprehensive support system.

The delayed-release capsules are a big win, helping all those powerful ingredients reach your gut intact.

Whether you're after a men's or women's formula, this probiotic hits the mark with high-quality ingredients and added vitamins.

Plus, the 30-day guarantee adds peace of mind.

Overall, if you're looking for effective, expertly formulated gut support that promotes restful sleep, this probiotic deserves serious consideration.

Be sure to also check out the best palmitoylethanolamide supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Dr. Berg 60 Billion Probiotic on Amazon

Physician's Choice Probiotics Probiotics for Sleep

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 30ct
Highlights
Supports gut health
Survives stomach acid
Science-backed formulation

This probiotic packs a punch with 60 billion CFUs and ten carefully selected strains, making it a powerhouse for supporting gut health.

Its acid-resistant capsules ensure the good bacteria survive the stomach's harsh environment and reach your gut where they do their magic.

While it’s not a magic pill for sleep, a healthy gut can positively influence sleep quality over time.

Plus, it's third-party tested for purity, and manufactured right here in the USA with care.

Just remember, consistency is key—this isn’t an overnight fix, but for those serious about gut wellness, it’s a solid, science-backed choice.

Be sure to also check out the best tributyrin supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Physician's Choice Probiotics on Amazon

Ancient Nutrition Probiotics

Probiotics for Mental Clarity by Ancient Nutrition, Once Daily Probiotics 30Ct, Helps Promote Mental Clarity and Concentration, Supports Healthy Energy and More Restful Sleep, 25 Billion CFUs*
Highlights
Supports sleep & clarity
Clinically studied ingredients
Shelf-stable, easy to take

Ancient Nutrition's SBO Mental Clarity is a powerhouse that combines soil-based probiotics with organic fermented superfoods, including clinically studied ashwagandha.

This unique blend aims to promote both better sleep and mental focus — a rare combo!

With 25 billion CFU, it delivers potent support for digestion, energy, and immunity, all in a convenient once-daily capsule.

Plus, it's backed by modern science and tested by third-party labs, ensuring safety and efficacy.

While the bottle is small and reviews are limited, this supplement is a smart, simple choice for anyone seeking restful nights and sharper days.

Be sure to also check out the best laminitis supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Ancient Nutrition Probiotics on Amazon

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