12 Tributyrin Supplements That Stand Out

Discover the best tributyrin supplement to boost gut health and vitality with our quick, clear guide to top picks in a vibrant, concise format.
BrandMy RatingPrice
Bestvite
Most Wallet-Friendly
9.0/10
Peak Performance
Best for Gut Health
8.8/10
Health Plus
Best for Digestive Support
8.6/10
Healthy Gut
Most Effectiveness and Purity
8.8/10
Quorinthiumax
9.8/10

Best Tributyrin Supplement

Discover the secret to unlocking your gut’s full potential with tributyrin supplements, the unsung heroes in gut health innovation. These potent little capsules are tailored to provide swift, targeted support, transforming your wellness routine into a vibrant, flavor-filled journey. Dive in as we unveil the best options to elevate your health with speed and precision.

Most Wallet-Friendly: Bestvite ButyraBoost 300mg

BESTVITE ButyraBoost 300mg Tributyrin Complex (60 Vegetarian Capsules) - No Stearates - Vegan - Non GMO - Gluten Free - Butyrate Gut Health Supplement
Highlights
Supports gut health
Pure and non-GMO
Made in the USA

ButyraBoost stands out as the most wallet-friendly option without compromising quality.

Its innovative prebiotic complex containing tributyrin ensures targeted gut health support and promotes a positive mood through gut-brain signaling.

The addition of Sunfiber boosts fiber intake and further enhances short-chain fatty acid production.

Plus, it’s vegan, non-GMO, gluten-free, and manufactured in the USA—a winning combination for health-conscious consumers.

While some may find the long-term effects still need more clarity, its affordable price point and high-quality standards make it a top choice for those wanting effective gut support on a budget.

Be sure to also check out the best triterpene supplements for more options! Also, here is the price history so you know exactly when to buy!

Price history for Bestvite ButyraBoost 300mg on Amazon

Best for Gut Health: Peak Performance CoreBiome

CoreBiome Tributyrin Postbiotic Supplement Clinically Tested For Gut Health. More Effective than Sodium Butyrate Capsules. High Bioavailability Post Biotics For Digestive, Leaky Gut, Colon, Microbiome
Highlights
Clinically backed ingredients
Supports gut & immune health
Allergy-free formulation

CoreBiome Tributyrin Postbiotic stands out as the best for gut health, backed by compelling clinical evidence.

Unlike many flashy, unverified supplements, this one uses patented Tributyrin to effectively reach the colon, boosting beneficial bacteria like F. prausnitzii and Anaerostipes.

The high bioavailability means your gut gets the support it needs, promoting a healthier microbiome and intestinal walls.

Plus, it's allergy-free and manufactured in the USA under strict GMP standards.

While the price may be steep, the proven results and commitment to quality make it a worthwhile investment for overall digestive and immune health.

Be sure to also check out the best sirtuin supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Peak Performance CoreBiome on Amazon

Best for Digestive Support: Health Plus Revitalize+

Health Plus Revitalize+ Corebiome Tributyrin Postbiotics for Complete Digestive Health, Leaky Gut, Colon | Gut Health Supplements for Men & Women | 60 Capsules, 30 Servings
Highlights
Clinically tested effectiveness
Supports gut & immune health
Passes through stomach

Revitalize+ Corebiome combines patented tributyrin with added digestive-supporting ingredients, targeting leaky gut, gut lining integrity, and overall gut health.

This formula is designed to go beyond just gut support—it also boosts immune health and fights oxidative stress.

The patented Tributyrin passes through the stomach, delivering support directly to the colon, making it especially effective for gut lining repair and maintaining homeostasis.

While the capsule size is slightly larger, the clinically tested effectiveness and dual support for digestion and immunity make it a top-tier choice for those seeking comprehensive gut health.

Be sure to also check out the best liquid supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Health Plus Revitalize+ on Amazon

Most Effectiveness and Purity: Healthy Gut

Tributyrin-X | Histamine and Leaky Gut Support | 99% Pure w/Zero Odor | 90 Servings
Highlights
Restores gut health
High bioavailability
Easy-to-swallow capsules

Tributyrin-X provides 99.9% pure tributyrin in convenient, odorless gel capsules, ensuring high bioavailability for maximum gut support.

It’s an effective choice for tackling leaky gut, reducing bloating, and normalizing bowel movements.

The capsules are super easy to swallow and free from fillers, sugar, gluten, and other unnecessary additives—perfect for sensitive stomachs.

While it takes some time to see results and contains sorbitol, its purity and professional-grade quality make it a top contender for anyone seeking a potent and clean postbiotic.

Be sure to also check out the best genistein supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Healthy Gut  
on Amazon

Quorinthiumax

Tributyrin Supplement for Gut & Immune 800mg | High Bioavailability with Microencapsulated Probiotics & Prebiotics - Advanced Liquid-Filled Tributyrin Complex, Gluten Free, 180 Capsules
Highlights
High-Potency Formula
Improved Absorption
Easy-to-Swallow Capsules

The 800mg of concentrated Tributyrin ensures a potent dose aimed at supporting gut health directly.

The microencapsulation technology is a game changer, preserving the formula's integrity and delivering active ingredients straight to your gut with maximum efficiency.

Plus, the probiotic and prebiotic complex works in tandem to bolster digestive harmony — a true synergistic approach.

The inclusion of Curcumin, Black Cumin Seed Oil, and Ginger Extract offers added anti-inflammatory benefits.

And with easy-to-swallow, liquid-filled capsules, absorption is swift and stomach comfort is prioritized.

Despite the higher price and limited reviews, its high potency and innovative delivery make it a top contender for gut health enthusiasts.

Be sure to also check out the best broccoli supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Quorinthiumax on Amazon

Tri-Butyrin Supreme

Designs for Health Tri-Butyrin Supreme - 3-in-1 Butyric Acid (Butyrate) Postbiotics for Gut Health & Gut Permeability Support - Tributyrin Supplement with Odor-Minimizing Innovation (60 Softgels)
Highlights
Supports gut health
Clinically trusted brand
Pure & gluten-free

Tributyrin provides a targeted delivery of butyrate, supporting gut health by promoting a balanced intestinal flora and helping to maintain colon integrity.

Its triple encapsulation ensures that the active compounds reach your gut effectively.

Plus, being gluten-free and formulated by a trusted, clinician-approved brand gives us confidence in its purity and efficacy.

While some users may see short-term results and others might notice variability, overall, this supplement stands out for those seeking a clinically trusted option to complement their GI health routine.

Be sure to also check out the best laminitis supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Tri-Butyrin Supreme on Amazon

Healus Complete Biotic Tributyrin Supplement

Complete Biotic - Postbiotic Tributyrin Supplement - Postbiotics for Gut Health - Butyrate Gut Health Supplement
Highlights
High bioavailability
Pure liquid form
Patented delayed release

Healus Complete Biotic stands out because of its 98% pure liquid Tributyrin, offering superior bioavailability compared to powders.

The patented delayed release capsules ensure the active ingredients reach your gut intact and effective, maximizing benefits for digestion, immune support, and even brain health.

Although it comes at a higher price, the quality, purity, and clinical backing from a trusted US brand make it worth the investment.

With each capsule containing 500mg of Tributyrin, you’re getting a potent, well-designed supplement that truly delivers.

For anyone seeking an advanced, clinically-supported solution, Healus Complete Biotic is a fantastic choice.

Be sure to also check out the best theobromine supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Healus Complete Biotic on Amazon

SANE MD

SANE MD - Viscera 3 Postbiotics with Tributyrin - Sodium Butyrate Supplement for Gas and Bloating Relief - Gut Health - IBS & Leaky Gut Butyric Acid Supplement - NSF Certified - 30 Capsules
Highlights
Effective gut relief
Powerful postbiotics
High-quality ingredients

Viscera-3 POSTbiotics delivers triple the power of other sodium butyrate supplements, targeting gut relief more effectively.

This supplement excels at reducing uncomfortable gas, bloating, and even IBS symptoms.

The key is its delivery of postbiotics directly to your lower colon, creating a healthier gut environment from the inside out.

Plus, the use of high-quality, NSF and GMP-certified ingredients gives us confidence in its safety and efficacy.

While the price is on the higher side for the small supply, the potential for long-term gut health makes it a worthy investment for those seeking real digestive relief.

Be sure to also check out the best relora supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for SANE MD on Amazon

VITACRLLYNMN Tributyrin

Tributyrin Supplement - Butyrate Precursor for Gut Barrier Support, Leaky Gut Support, Digestion 60 Count
Highlights
Supports gut health
Effective mood improvement
Natural, safe ingredients

The 900mg Tributyrin per capsule ensures a potent dose of butyrate precursor, which is fantastic for supporting a healthy gut environment.

Plus, with 11 in 1 supplement complex, it goes beyond gut health by boosting overall well-being with ingredients like pomegranate extract, bromelain, and mushroom complex. VITACRLLYNMN emphasizes natural, safe ingredients—no GMOs or chemicals—which gives us peace of mind.

While some users mention capsule dosage confusion and a moderate rating, the formula's focus on gut barrier support and overall quality makes it a promising choice for those prioritizing natural gut health solutions.

Be sure to also check out the best synephrine supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for VITACRLLYNMN Tributyrin on Amazon

The Perfect Stool Tributyrin Supplement

Tributyrin-Max Postbiotic Butyrate Supplement; Bloating, Gas and Leaky Gut Support; Perfect, Clean Wipe Poops; 750 mg Enteric Capsules; 3rd Party Tested Gluten/Dairy-Free
Highlights
High dose (750mg)
Supports healthy gut
Seals leaky gut

Tributyrin-Max delivers a whopping 750 mg per capsule, making it one of the most potent options on the market — fewer pills, more impact.

Its targeted, slow-release formula ensures that butyrate is delivered directly to the gut, supporting a healthy microbiome, sealing leaks, and reducing inflammation.

Ideal for those needing to firm up loose stool or support gut healing, especially during antibiotic use.

While it does come at a higher price point and isn’t a miracle for everyone, its powerful dose and proven benefits make it a top contender for anyone serious about gut health.

Be sure to also check out the best fucoidan supplements for more options! Also, here is the price history so you know exactly when to buy!

Price history for The Perfect Stool on Amazon

Ritual Synbiotic+

Ritual Synbiotic+ Probiotic, Prebiotic, Postbiotic, 3-in-1 Formula for Gut and Digestive Health, Regularity, Bloat, Immune Support, Vegan Delayed-Released Capsule, Women and Men, 30 Day
Highlights
Supports gut health
Easy to swallow
No refrigeration needed

SYNBIOTIC+ offers a comprehensive gut support formula with prebiotics, probiotics, and postbiotics, all backed by a traceable supply chain.

Its delayed-release capsule ensures the probiotics reach the colon alive, boosting their effectiveness.

Plus, the inclusion of minty tabs makes daily consumption more enjoyable.

While some may find it a bit pricey and wish for clearer ingredient transparency, we appreciate its thorough third-party testing and commitment to quality.

Overall, if you're seeking a potent, well-designed supplement, this one definitely deserves a spot on your shortlist.

Be sure to also check out the best ip6 supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Ritual Synbiotic+ on Amazon

Gundry MD Bio Complete 3

Gundry MD® Bio Complete 3, 3-in-1 Probiotics for Gut Health, Probiotic Supplements for Digestion, Supplement Supporting Bloating, Gas, Food Cravings, Energy Levels, Skin, and Focus, 30 Day Supply
Highlights
Supports gut health
Enhances digestion
Boosts energy levels

Bio Complete 3 from Gundry MD shines when it comes to supporting gut health and digestion.

Its powerful blend of probiotics, prebiotics, and postbiotics promotes smoother digestion and can help reduce bloating and discomfort—making it a solid choice for those seeking quick gut relief.

Plus, it offers cognitive support, helping you stay focused by nurturing your gut-brain connection.

The added bonus?

Healthier skin and increased energy to keep you feeling vibrant throughout the day.

However, watch out for potential nausea or bloating, especially if you're sensitive.

Price-wise, it’s a little steep, but the health benefits might just be worth it.

Be sure to also check out the best glycerol supplement for more options! Also, here is the price history so you know exactly when to buy!

Price history for Gundry MD Bio Complete 3 on Amazon

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