18 Top Digestive Enzymes for MTHFR Support

Discover the best digestive enzymes for MTHFR to boost your gut health with quick, effective relief and energetic living. Find your ideal supplement today.
BrandMy RatingPrice
Physician's Choice
Best Price-to-Performance
8.6/10
Zenwise Health
Best for Digestive Support
8.8/10
Life Extension
Best for MTHFR Sensitivities
9.0/10
Now Foods
Best for Fat and Protein Digestion
9.2/10
Thorne
9.2/10

Best Digestive Enzymes for Mthfr

Navigating the world of digestive health can feel like decoding a complex puzzle, especially for those with MTHFR mutations. Finding the right digestive enzymes is like discovering a secret weapon — a small but mighty aid to support optimal digestion and nutrient absorption. Let’s delve into the best enzyme options to help you conquer discomfort and boost vitality with ease.

Best Price-to-Performance: Physicians Choice Digestive Enzymes

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT
Highlights
Digestive support for all foods
Survive gut acidity
Scientifically formulated

With 16 beneficial enzymes that target proteins, carbs, fruits, veggies, beans, dairy, and fats, it truly covers all bases—perfect for all diets.

The inclusion of SBO probiotics and prebiotics enhances gut health, making digestion smoother and more efficient.

What sets it apart is its scientific backing and premium quality, with ingredients guaranteed to survive your gut’s harsh environment.

Best yet, it offers incredible value without sacrificing performance—a fantastic choice for anyone seeking reliable, comprehensive digestive support on a budget.

Be sure to also check out the best digestive enzymes for vegans for more options! Also, here is the price history so you know exactly when to buy!

Price history for Physicians Choice Digestive Enzymes on Amazon

Best for Digestive Support: Zenwise Health Digestive Enzymes

Zenwise Health Digestive Enzymes and Bromelain for Gut Health - Probiotic Multi Enzymes with Prebiotics and Probiotics for Women and Men for Digestive Health and Bloating Relief for Digestion - 100 CT
Highlights
Fast-Acting Relief
Clinically Proven Ingredients
Supports Gut Flora

the 3-in-1 formula really packs a punch—combining lab-proven enzymes, bromelain, papain, and probiotics to target multiple digestive issues at once.

The fast-acting enzymes start working immediately, breaking down food up to 39% more completely, which means you feel relief faster.

Plus, the probiotics guarantee survival through your digestive journey, supporting overall gut health from within.

This plant-based combo not only alleviates bloating, gas, and discomfort but also helps nourish your microbiome for longer-term digestive harmony.

Perfect for broad, quick support!

Be sure to also check out the best digestive enzymes for gluten intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for Zenwise Health Digestive Enzymes on Amazon

Best for MTHFR Sensitivities: Life Extension Super Digestive Enzymes

Life Extension Enhanced Super Digestive Enzymes & Probiotics -Vegetarian-Friendly Digestive Health Formula For GI Balance - Plant-Based Diet Aid - Non-GMO - 60 Vegetarian Capsules
Highlights
Effective digestion relief
Includes probiotics support
High-quality ingredients

As the "Best for MTHFR Sensitivities", it hits all the right notes.

This vegetarian-friendly, plant-based blend combines ten essential enzymes with probiotic B. coagulans, offering comprehensive digestive support while remaining allergen-free and suitable for sensitive individuals.

It effectively helps break down your greens, legumes, and fats, reducing bloating and discomfort.

Plus, the high-quality, non-GMO ingredients give us confidence in its purity.

While it might be pricier and could cause minor stomach upset in some, the benefits for those with sensitivities are undeniable.

A solid choice for gentle, thorough digestion support.

Be sure to also check out the best digestive enzymes with hcl for more options! Also, here is the price history so you know exactly when to buy!

Price history for Life Extension Super Digestive Enzymes on Amazon

Best for Fat and Protein Digestion: NOW Super Enzymes

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules
Highlights
Supports healthy digestion
Optimizes nutrient absorption
Keto and gluten free

NOW Super Enzymes stands out as the best for fat and protein digestion thanks to its broad spectrum of enzymes like bromelain, ox bile, pancreatin, and papain.

These work together to break down fats, carbs, and proteins more efficiently, helping you absorb nutrients better.

The formula is keto-friendly, gluten-free, and soy-free, making it suitable for sensitive stomachs.

Plus, it’s GMP-certified in the USA, ensuring quality.

Keep in mind, some users report mild stomach discomfort or a strong smell, but overall, this supplement is a solid choice for enhancing digestion.

Be sure to also check out the best digestive enzymes with ox bile for more options! Also, here is the price history so you know exactly when to buy!

Price history for NOW Super Enzymes on Amazon

Thorne

THORNE Advanced Digestive Enzymes (Formerly Bio-Gest) - Blend of Digestive Enzymes to Aid Digestion - Gut Health Support with Pepsin, Ox Bile, Pancreatin - 180 Capsules - 90 Servings
Highlights
Supports Indigestion Relief
Promotes Nutrient Absorption
Trusted by Experts

Thorne's digestive enzyme blend is comprehensive and effective, combining hydrochloric acid, pepsin, pancreatin, and ox bile to support those with occasional indigestion, especially if you've had your gallbladder removed or experience food sensitivities.

The formula works well to ease discomfort after heavy or fatty meals and improves nutrient absorption, which is a big win for overall health.

Plus, being trusted by top-tier professionals and Olympic teams gives us confidence in its quality.

Just keep in mind, it might require consistent use, and sensitive stomachs should approach with caution.

Be sure to also check out the best digestive enzyme with hcl for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne on Amazon

Pure Encapsulations Digestive Enzymes Ultra

Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules
Highlights
Improves bloating relief
Supports nutrient absorption
Broad-spectrum enzymes

Pure Encapsulations offers a broad-spectrum blend of vegetarian enzymes that truly support nutrient bioavailability, making digestion smoother and more efficient.

The added Betaine HCl helps maintain the right gastric pH, working hand-in-hand with the enzymes to break down proteins, fiber, and dairy with ease.

We appreciate its clean formula—free from allergens, GMOs, and artificial nasties—which aligns well with a health-conscious lifestyle.

While it comes at a slightly higher price, the quality and performance make it a worthwhile investment for those with MTHFR concerns looking to optimize digestion.

Be sure to also check out the best magnesium for mthfr for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Encapsulations Digestive Enzymes Ultra on Amazon

Pure Encapsulations Digestive Enzymes Ultra Digestive Enzymes for Mthfr

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules
Highlights
Supports nutrient absorption
Helps digestion of dairy
Plant-based enzyme stability

The vegetarian enzyme blend is thoughtfully designed to boost nutrient bioavailability and support smooth digestion, especially for those with MTHFR who need careful nutrient absorption.

It excels at breaking down proteins, dairy, and complex carbs, reducing bloating and gas, which can be common concerns.

Plus, the broad pH activity means it works well across different stomach environments.

We appreciate that Pure Encapsulations keeps it free from allergens, artificial ingredients, and GMOs—making it a clean choice.

While results can vary, this supplement offers a reliable, plant-based option for enhanced digestion.

Be sure to also check out the best digestive gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Encapsulations Digestive Enzymes Ultra on Amazon

Doctor's Best Digestive Enzymes

Doctors Best Digestive Enzymes, Supports Digestive Wellness, Non-GMO, Vegetarian 90 Veggie Caps
Highlights
Broad spectrum enzymes
Gluten-free & Vegetarian
Reasonably priced

Doctor's Best Digestive Enzymes offers a broad spectrum of enzymes, making it versatile for various dietary needs.

It's gluten-free, vegetarian, and backed by science-based nutrition, which gives us confidence in its quality.

Since it's reasonably priced, it’s a great option for those looking to support digestion without breaking the bank.

Plus, its non-GMO status is a nice bonus.

While it isn’t the most potent formula out there and has limited reviews, it’s a solid choice for anyone needing gentle, broad-spectrum enzyme support, especially for MTHFR sensitivities.

Be sure to also check out the best creatine for teens for more options! Also, here is the price history so you know exactly when to buy!

Price history for Doctor's Best Digestive Enzymes on Amazon

Digestzymes

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)
Highlights
Supports Food Breakdown
Relieves Gas/Bloating
Clinically Trusted Brand

It offers a robust multi-enzyme blend paired with betaine HCl, specifically crafted to support optimal digestion of proteins, fats, and carbs.

Many users notice relief from occasional gas, bloating, and that uncomfortable feeling of fullness after meals.

Plus, the inclusion of bile salts helps with fat absorption, making it a well-rounded choice for those with malabsorption concerns.

We appreciate that it's from DFH, a reputable brand trusted by practitioners.

However, some may experience occasional heartburn, and reordering might be necessary to keep the benefits flowing.

Be sure to also check out the best electrolytes for fasting for more options! Also, here is the price history so you know exactly when to buy!

Price history for Digestzymes on Amazon

MaryRuth Organics Ultra Digestive Enzymes Digestive Enzymes for Mthfr

MaryRuth Organics Ultra Digestive Enzymes Capsules | Up to 2 Month Supply | Supplement for Gut Health Support | Digestion & Immune Support with Amylase | Lipase & Lactase | Vegan | 60 Count
Highlights
Enhances digestion efficiency
Supports nutrient absorption
Vegan and gluten-free

MaryRuth's Ultra Digestive Food Enzymes offer a comprehensive blend of enzymes, covering everything from lactose to fiber digestion, which is perfect for those with MTHFR who need that extra support.

The vegan and clean-label formula gives us peace of mind, knowing it’s free from common allergens and made in a GMP-certified facility.

While it includes maltodextrin—which might be a concern for some—and has a limited scope of digestion, its ease of use and potent enzyme mix make it a solid choice for boosting digestion and nutrient absorption in a pinch.

Be sure to also check out the best electrolyte for horses for more options! Also, here is the price history so you know exactly when to buy!

Price history for MaryRuth Organics Ultra Digestive Enzymes on Amazon

Now Foods Full Spectrum Enzymes

NOW Foods Supplements, Optimal Digestive System, Full Spectrum Enzymes, 90 Veg Capsules
Highlights
Helps digest large meals
Vegan and allergen-free
Effective for bloating

NOW Optimal Digestive System offers a comprehensive full spectrum of enzymes, making it a versatile choice for tackling a variety of foods, especially beans and cruciferous veggies often challenging for MTHFR individuals.

The Vegan and GMO-free certification adds peace of mind, ensuring it aligns with clean, ethical standards.

While it does require taking two capsules per meal—a small inconvenience—it’s a small price for noticeable relief from bloating and indigestion.

Plus, the effectiveness tends to build over time, so consistency is key.

Overall, it’s a reliable, plant-based option for boosting digestion in a busy lifestyle.

Be sure to also check out the best lactase enzyme tablets for more options! Also, here is the price history so you know exactly when to buy!

Price history for Now Foods Full Spectrum Enzymes on Amazon

NewRhythm Digestive Enzymes

NewRhythm Digestive Enzymes 245 mg, with Probiotics and Prebiotics, Plant Based, 7 Key Enzymes, Digestion, Nutrient Absorption, Protease Amylase & Lipase, 60 Vegan Capsules
Highlights
Made in USA
Plant-Based Enzymes
Supports Regularity

Here’s why: NewRhythm Digestive Enzymes harness the power of plant-based ingredients, making them perfect for vegans and those avoiding animal products.

Made right here in the USA in a GMP-certified facility, they promise top-tier quality.

The blend includes enzymes like bromelain, papain, and lipase—supporting digestion across a wide array of foods, especially for complicated MTHFR-related sensitivities.

Plus, the added probiotics and prebiotics help restore gut balance and reduce bloating, so you can enjoy your meals without worry.

While the strain strength could be beefed up, it’s a natural, clean option that keeps your digestion happy!

Be sure to also check out the best electrolytes for hashimoto's for more options! Also, here is the price history so you know exactly when to buy!

Price history for NewRhythm Digestive Enzymes on Amazon

Garden of Life Digestive Enzymes Digestive Enzymes for Mthfr

Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables
Highlights
Organic, plant-based enzymes
Easy to chew
Pleasant tropical flavor

Organic Digest+ from Garden of Life is a delightful, plant-based enzyme that confidently supports digestion of proteins, fats, and carbs.

Its tropical flavor makes taking it a joy, and the chewable tablet is perfect for on-the-go routines.

Crafted with Certified Organic fruits and vegetables, it delivers real food-based nutrients, backed by science and third-party certification.

While the chalky texture might be a bit quirky, the all-natural, gluten-free, vegan formulation makes it a great choice for MTHFR individuals seeking a clean, effective digestive aid.

Be sure to also check out the best vitamins for traveling for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life Digestive Enzymes on Amazon

Physicians Choice

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Bromelain, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Bloating & Meal Time Discomfort - Dual Action - All Diets - 30 CT
Highlights
Comprehensive enzyme coverage
Supports gut health
High-quality ingredients

Our team loves that it packs a punch with 16 diverse enzymes, tackling proteins, carbs, dairy, fruits, veggies, and fats – perfect for a varied diet.

The addition of SBO probiotics and prebiotics means your gut gets extra support, promoting overall digestion and comfort.

The dual-action formula works both on breaking down food efficiently and nurturing gut flora, which is a game-changer.

Made with science-backed ingredients and third-party tested for quality, it offers peace of mind.

While it doesn’t promote weight loss, it's a reliable choice for supporting healthy digestion and reducing mealtime discomfort.

Be sure to also check out the best iron supplement for mthfr for more options! Also, here is the price history so you know exactly when to buy!

Price history for Physicians Choice on Amazon

Double Wood Digestive Enzymes

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood
Highlights
Contains all 10 enzymes
Supports digestion of fats
High-quality, pure ingredients

Double Wood's Vitazyme stands out because it contains all 10 essential digestive enzymes, making it a powerhouse for breaking down proteins, fats, and carbs.

The core pancreatic enzymes—Amylase, Lipase, and Protease—are top-notch, supporting efficient digestion and reducing bloating.

Plus, the pure, high-quality ingredients ensure you're fueling your gut with the best.

While the limited reviews are a small caveat, the 4.5-star rating and solid formulation suggest this supplement could be a game-changer for MTHFR sufferers looking to optimize their digestive health effortlessly.

Be sure to also check out the best b complex for mthfr for more options! Also, here is the price history so you know exactly when to buy!

Price history for Double Wood Digestive Enzymes on Amazon

Source Naturals Essential Enzymes Digestive Enzymes for Mthfr

Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules
Highlights
Supports multiple food groups
Easy to swallow capsules
Affordable alternative

Source Naturals’ Essential Enzymes deliver a robust blend of enzymes that target carbs, proteins, fats, and fiber — a true all-in-one for your digestion.

The capsules are easy to swallow and versatile, whether you take them with water or sprinkle over food (just avoid hot dishes).

While it doesn't focus specifically on MTHFR, its broad support can still be beneficial for many dealing with digestion issues.

Plus, with over 40 years of trust and a reasonable price point, it’s a reliable choice for those seeking to optimize nutrient absorption effortlessly.

Be sure to also check out the best vegan digestive enzymes for more options! Also, here is the price history so you know exactly when to buy!

Price history for Source Naturals Essential Enzymes on Amazon

Enzymedica Digest Gold

Enzymedica Digest Gold + ATPro, Maximum Strength Digestive Enzymes, Helps Digest Large Meals for Instant Bloating Relief, 90 Count
Highlights
Fast digestion support
Reduces bloating effectively
Vegan and clean label

Enzymedica’s full-strength blend is a powerhouse for food lovers who want worry-free indulgence.

Its Thera-blend enzymes work effectively across different pH levels, ensuring faster digestion and less bloating—perfect for those extra-cheesy nights or hearty meals.

Plus, the ATPro blend energizes your post-meal experience, fueling your day with ATP, CoQ10, and magnesium.

It’s vegan, clean, and free from common allergens, making it a safe choice for many.

While it may require daily use, its potent, natural ingredients make it a reliable companion to support your MTHFR needs and digestion health.

Be sure to also check out the best prenatal vitamin for mthfr mutation for more options! Also, here is the price history so you know exactly when to buy!

Price history for Enzymedica Digest Gold on Amazon

Enzymedica Digest Gold

Enzymedica Digest Gold + ATPro, Maximum Strength Enzyme Formula, Prevents Bloating and Gas, 14 Key Enzymes Including Amylase, Protease, Lipase and Lactase, 21 Capsules
Highlights
Effective digestive support
Reduces bloating and gas
Easy to swallow

Its Thera-blend enzyme formula works effectively throughout the entire digestive process, no matter the pH level, ensuring faster relief from bloating and indigestion.

The added ATPro Blend energizes your cells post-meal, so you feel less sluggish after indulging.

Plus, with just one capsule a day, it comfortably tackles a hefty meal—up to 34g of fat, 16g of protein, and 86g of carbs—making digestion smoother without sacrificing your favorite foods.

Clean, vegan, and free from common allergens, it’s a versatile choice for MTHFR folks seeking reliable support, though some users report mixed symptom reactions.

Be sure to also check out the best systemic enzymes for more options! Also, here is the price history so you know exactly when to buy!

Price history for Enzymedica Digest Gold on Amazon

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