15 Energy Supplements for Chronic Fatigue That Work

Discover the best energy supplements for chronic fatigue to boost vitality fast. Find your perfect energizer and reclaim your daily groove with our expert picks.
BrandMy RatingPrice
Unknown
Most Cost-Effective
8.2/10
Trp the Relief Products
Best for Chronic Fatigue Fighters
7.2/10
Olly
Best for Busy Professionals
8.8/10
Resciency
Best for Mitochondrial Support
8.8/10
Naturalife Labs a Higher Standard
9.0/10

Best Energy Supplements for Chronic Fatigue

Feeling perpetually drained and running on empty? Discover the vital boost your body craves with our curated list of the best energy supplements for chronic fatigue, designed to revitalize your mind and body swiftly. Dive in to unlock the secret weapons for reclaiming your vitality, one powerful supplement at a time.

Most Cost-Effective: Super Energy Tablets

MASON NATURAL Super Energy with Guarana, Panax Ginseng & Kola Nut - Herbal Complex Formula to Support Optimal Performance & Energy*, 60 Tablets
Highlights
Boosts Energy Quickly
Supports Chronic Fatigue
Easy to Take

This supplement delivers a rapid energy boost, making those sluggish days a little easier to conquer.

Its support for chronic fatigue is notable, helping you stay alert and energized without the crash.

Plus, it’s super easy to incorporate into your daily routine, whether in capsule or powder form.

As our Most Cost-Effective choice, it packs a punch with ingredients like ATP, CoQ10, and PQQ—providing a robust mitochondrial boost at a budget-friendly price.

Keep in mind, some may experience side effects, and regular use might be necessary for sustained benefits, but overall, it's a smart, value-packed option for those seeking energy support.

Be sure to also check out the best energy supplement for dogs for more options! Also, here is the price history so you know exactly when to buy!

Price history for Super Energy Tablets on Amazon

Best for Chronic Fatigue Fighters: TRP Chronic Fatigue Tablets

The Relief Products Chronic Fatigue Therapy Fast Dissolving Tablets for Fatigue, Weakness, Tiredness, CFS 70 Ct, 70 Count
Highlights
Natural multi-symptom relief
Fast-dissolving tablets
No jitters or crashes

This supplement excels as "Best for Chronic Fatigue Fighters" thanks to its natural blend of ingredients like ginseng, echinacea, and ginkgo biloba, designed specifically to support those battling persistent exhaustion.

The fast-dissolving tablets make it easy to incorporate into any routine, with no jitters or crashes—just gentle, steady relief.

Keep in mind, though, that it may take several weeks to notice full benefits, and effectiveness can vary between individuals.

Still, if you're seeking a holistic, natural option for multi-symptom relief, this product is worth trying.

Be sure to also check out the best allergy supplements for dogs for more options! Also, here is the price history so you know exactly when to buy!

Price history for TRP Chronic Fatigue Tablets on Amazon

Best for Busy Professionals: Olly Daily Energy Gummies

OLLY Daily Energy Gummy, Caffeine Free, Vitamin B12, CoQ10, Goji Berry, Adult Chewable Supplement, Tropical Flavor - 60 Count
Highlights
Supports cellular energy
Delicious tropical flavor
Caffeine free

OLLY Daily Energy Gummies stand out as a top choice for busy professionals needing a quick, worry-free energy boost.

These convenient, caffeine-free gummies blend tropical passion fruit flavor with powerful ingredients like B12, CoQ10, and Goji Berry—nature’s ancient superfoods.

They’re easy to incorporate into your daily routine: just chew two gummies and go!

We love that they support cellular energy without jitters or crash, making them perfect for demanding days.

The flavor might not appeal to everyone, but if you're after an effective and tasty way to maintain your vitality, these are a solid pick!

Be sure to also check out the best calcium supplement for chickens for more options! Also, here is the price history so you know exactly when to buy!

Price history for Olly Daily Energy Gummies on Amazon

Best for Mitochondrial Support: Resciency

2326 MG Mitochondrial Supplements with ATP, Vitamins, CoQ10 & PQQ, More Effective Than Creatine HMB & Nitric Oxide, Energy, Endurance, Strength, Recovery & Muscle, Organic, 120 Capsules
Highlights
Sustained energy boost
Natural and organic ingredients
Improves focus and clarity

This extra strength mitochondrial booster delivers a powerhouse blend of ATP, CoQ10, and PQQ, all organically sourced to support cellular energy at its core.

It effectively reduces fatigue and boosts endurance, making it perfect for those battling chronic exhaustion.

The inclusion of Black Pepper Extract ensures high absorption, so your body gets the most out of every dose.

Plus, the organic beetroot and maca root add a natural energy lift without synthetic fuss.

Just be prepared for a slightly bitter aftertaste, but overall, it’s a top-tier choice for sustained vitality.

Be sure to also check out the best iron supplement for bariatric patients for more options! Also, here is the price history so you know exactly when to buy!

Price history for Resciency on Amazon

NaturaLife Labs Acetyl L-Carnitine

Acetyl L-Carnitine 1,500 mg High Potency Supports Energy Production, Sports Nutrition, Supports Memory/Focus - 100 Veggie Capsules
Highlights
High potency dose
Third-party tested
Easy-to-take capsules

The high potency formula delivers a solid 1500 mg per capsule, making it a powerful option for tackling chronic fatigue.

Plus, it’s completely free from fillers and binders, so you're only getting the purest form of acetyl-L-carnitine.

The easy-to-swallow capsules fit seamlessly into busy schedules, and knowing it’s manufactured in an FDA-registered facility with third-party testing gives us confidence in its safety and quality.

While results can vary and it might take some time to see effects, this supplement is a reliable choice to boost energy levels naturally.

Be sure to also check out the best endurance supplements for runners for more options! Also, here is the price history so you know exactly when to buy!

Price history for NaturaLife Labs Acetyl L-Carnitine on Amazon

Corlia NADH 50mg + CoQ10 200mg + D-Ribose 150mg

NADH 50mg + CoQ10 200mg + D-Ribose 150mg Supplement, Enhance NAD+ Supplement for Energy, Fatigue, Reduced Nicotinamide Adenine Dinucleotide, 120 Veggie Capsules
Highlights
Enhanced energy support
High absorption technology
Vegan friendly formula

Corllia's NADH supplement truly stands out with its cutting-edge absorption technology thanks to patented Curdisol-QR, which delivers up to 5x the bioactive benefits compared to standard Ubiquinol.

This vegan-friendly formula combines 50mg Reduced NADH, 200mg Ubiquinol, and 150mg D-Ribose to boost your ATP production effectively.

Plus, with just one capsule daily, you'll get a consistent dose that supports your energy needs without fuss.

Though it requires international shipping and some long-term data is pending, it’s a trusted, easy-to-use solution for fighting chronic fatigue with a scientifically-backed punch.

Be sure to also check out the best fertility supplements for couples for more options! Also, here is the price history so you know exactly when to buy!

Price history for Corlia NADH 50mg + CoQ10 200mg + D-Ribose 150mg on Amazon

Genius Mushroom Energy Supplements for Chronic Fatigue

Genius Mushroom Supplement - Lions Mane, Cordyceps, Reishi - Brain Nootropic for Energy, Focus, Overall Wellness, & Immune Support - 90 Capsules
Highlights
Enhances mental clarity
Supports focus and mood
Vegan and paleo friendly

Genius Mushrooms by The Genius Brand packs a punch with scientifically-supported fungi like Lion’s Mane and Cordyceps to boost focus and energy naturally.

It’s perfect for those looking to elevate mental clarity without relying on caffeine.

Plus, it’s vegan, paleo, and keto-friendly, making it accessible for many diets.

The capsules are a bit sizable, but that's a small trade-off for the quality ingredients.

Keep in mind, as with any supplement, results can vary.

Overall, it’s a smart, clean choice for fighting chronic fatigue and staying sharp throughout the day.

Be sure to also check out the best mineral supplement for water for more options! Also, here is the price history so you know exactly when to buy!

Price history for Genius Mushroom on Amazon

One A Day

One A Day Energy Daily Essentials Multivitamin, Energy Supplement to Support Physical Energy & Mental Alertness Support with Vitamin B6, Vitamin B12, Caffeine & Folic Acid, 120 Count
Highlights
Boosts mental alertness
Contains essential B vitamins
Supports daily energy

The One A Day Daily Essentials Energy Multivitamin is a convenient way to support both your mental alertness and physical energy in one shot.

It’s packed with essential B vitamins like B1, B2, B6, and B12, which are fantastic for helping your body convert food into usable fuel.

Plus, the added caffeine gives you that extra mental boost when you need it most.

While the tablet size might be a tad large and it may cause nausea in some, its comprehensive nutrient profile makes it a solid choice for combating chronic fatigue — especially if you’re after a quick, no-fuss supplement.

Be sure to also check out the best joint supplements for great danes for more options! Also, here is the price history so you know exactly when to buy!

Price history for One A Day on Amazon

Secrets of the Tribe

Chronic Fatigue Secret 120 Capsules, 1000 mg, Korean Red Ginseng, Rhodiola, Reishi Mushroom, Rehmannia, Ashwagandha, Echinacea. Energy/Endurance Formula (120 Capsules)
Highlights
Pure, Natural Ingredients
High Potency Formula
Easily Absorbed

Secrets of the Tribe offers a 100% natural formula with high potency, ensuring you get maximum benefits without any artificial additives.

The easily absorbed blend makes it ideal for quick energy boosts, especially for those battling chronic fatigue.

While it isn't lab tested, the product’s purity claims and herb ID confirmation give us confidence in its quality.

Plus, made entirely in the USA, it aligns with clean, transparent sourcing.

If you're seeking a clean, potent supplement that your body can readily utilize, this one’s definitely worth considering.

Be sure to also check out the best supplements for pitbulls for more options! Also, here is the price history so you know exactly when to buy!

Price history for Secrets of the Tribe on Amazon

Pure Encapsulations Adrenal Energy Supplements for Chronic Fatigue

Pure Encapsulations Adrenal | Supplement to Support Healthy Cortisol Levels, Fatigue, Stress Moderation, and Adrenal Gland Function* | 60 Capsules
Highlights
Supports adrenal health
Made with quality ingredients
Helps with stress management

_Pure Encapsulations' Adrenal Support* offers a thoughtful blend designed to nurture your adrenal glands and maintain healthy cortisol levels.* Its premium ingredients, sourced from trusted suppliers, ensure you're getting a pure and potent formula—free from common allergens, GMOs, and artificial additives.

Many users report feeling more balanced and better equipped to handle stress, although some may experience jitteriness or sleep disturbances initially.

Patience is key, as the adjustment period can vary.

Overall, this supplement is a reliable choice for those seeking to boost energy and support adrenal health naturally.

Be sure to also check out the best iron supplement for cats for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Encapsulations Adrenal on Amazon

FreshCap Mushrooms

FreshCap 5-in-1 Energy Supplements, Energy Supplements for Women and Men, Energy Boosters for Fatigue, Energy Support, Cordyceps Extract, Ayurveda Cordyceps Mushroom Blend Capsules (120 Capsules)
Highlights
Natural, crash-free energy
Supports mental clarity
High-quality, pure ingredients

The blend of Cordyceps, Guayusa, and Guarana delivers natural, crash-free energy that keeps you going without the jitters or energy crashes typical of synthetic options.

The added Vitamins B6 and B12 give your mental clarity a nice boost, making it a great choice for those tackling demanding days.

Plus, it’s made from highest-quality, pure ingredients—no fillers, artificial additives, or grains—so you get all the benefits straight from nature.

While the earthy taste may not be for everyone and it comes at a higher price point, the overall power and purity make it worth considering for sustained vitality.

Be sure to also check out the best cranberry supplement for cats for more options! Also, here is the price history so you know exactly when to buy!

Price history for FreshCap Mushrooms on Amazon

Snap Supplements

Metabolism and Natural Energy Supplements for Fatigue, Stress Relief, Energy Booster & Better Mood, Energy Pills for Women & Men, Ginger, Turmeric, Rhodiola Rosea, 60 Capsules
Highlights
Effective energy boost
Easy to swallow
Reduces cravings

It provides an effective energy boost that helps combat those sluggish days, and it’s super easy to swallow, making it convenient for daily use.

Plus, if you're battling cravings, this supplement might just be your new best friend, as it actively helps to curb those urges.

That said, some users report it causing heartburn or feeling a bit pricey, and there's always a chance of allergic reactions.

Overall, if you’re seeking a natural pick-me-up and can handle the potential side effects, this could be a solid choice in your fatigue-fighting arsenal.

Be sure to also check out the best mushroom supplement for bloating for more options! Also, here is the price history so you know exactly when to buy!

Price history for Snap Supplements on Amazon

Innervisnution Energy Supplements for Chronic Fatigue

Energy & Mood Supplement – 60 Capsules 5-in-1 Blend Boost Energy Production Support Relaxation Fatigue Stress Relief Formula Mood Enhancer – Non-GMO & Lab Tested
Highlights
Sustained, steady energy
Reduces stress and fatigue
No artificial fillers

This energy and mood booster combines powerful natural ingredients like Magnesium, Maca, Ashwagandha, and Muira Puama to help fight chronic fatigue.

Users report steady energy without jitters and a noticeable reduction in stress levels.

The formulation is clean—free of artificial fillers or GMOs—which aligns with our standards for quality.

While some experienced slow results or mixed effectiveness, overall, it’s a reliable choice for those seeking a gentle boost and improved vitality.

Plus, being made in the USA adds peace of mind.

Be sure to also check out the best zinc supplement for goats for more options! Also, here is the price history so you know exactly when to buy!

Price history for Innervisnution on Amazon

NOW Foods B-12

NOW Foods Supplements, Instant Energy B-12 (2,000 mcg of B-12 per packet), Cellular Energy Boost*, 75 Packets
Highlights
Quick energy boost
Easy to take
Nice taste

Now Foods offers a quick energy boost that truly delivers, perfect for those dragging through long days of chronic fatigue.

It’s easy to take and boasts a pleasant taste that makes sticking to your routine hassle-free.

While the flavor options are somewhat limited, the high customer rating of 4.4 stars indicates satisfied users.

Just a heads-up — keep it away from pets, as a potential safety concern was mentioned.

Overall, it's a reliable, no-fuss choice that helps restore your energy levels without any complicated prep.

Be sure to also check out the best cranberry supplement for dogs uti for more options! Also, here is the price history so you know exactly when to buy!

Price history for NOW Foods B-12 on Amazon

Nutracelle Nutramin Energy Gummy

NUTRAMIN Energy Boost Vitamin Gummy - Skip The Coffee & Boost Your Energy, Caffeine-Free, Sugar-Free, Vegan, B12, Green Tea, Ashwagandha, Garcinia Cambogia, Raspberry Adaptogen - 90 ct
Highlights
No jitters or crash
Sugar and caffeine free
Delicious berry flavor

The Nutramin Energy Boost gummies deliver a delicious Berry Blast flavor that makes taking your daily dose enjoyable.

They're crafted without sugar or caffeine, making them suitable for those on keto, paleo, or Whole30 journeys who want an all-natural, non-habit forming way to enhance their energy levels.

While some users may find the energizing effect to be subtle, others report feeling a gentle lift without the jitters or crashes typical of synthetic supplements.

These gummies are packed with adaptogens like Ashwagandha and raspberry extract, which support stress adaptation and overall well-being.

Ideal for a consistent, healthy boost—especially if you're sensitive to traditional stimulants.

Be sure to also check out the best supplements for postpartum hormones for more options! Also, here is the price history so you know exactly when to buy!

Price history for Nutracelle Nutramin Energy Gummy on Amazon

Basigano Energy Supplements for Chronic Fatigue

Natural Dopamine Supplement for Energy, Focus, Motivation, Mental Alertness, Mood, and Stress - Non-GMO, Gluten-Free - 90 Tablets
Highlights
Enhances mood and well-being
Boosts natural dopamine levels
Supports mental clarity

Our advanced formula harnesses the power of 12 carefully selected ingredients like L-Tryptophan, L-Tyrosine, and Vitamin B6 to naturally boost dopamine levels.

This combination promotes improved mood, mental clarity, and sustained energy without the jitters.

The vegan and cruelty-free ingredients align perfectly with ethically conscious consumers.

While individual results can vary, many users notice a real difference in focus and motivation.

Be mindful that some might experience slight sleepiness, and pricing fluctuations could impact your purchase.

Overall, this supplement offers a trustworthy and natural way to fight chronic fatigue and feel invigorated daily.

Be sure to also check out the best calcium supplement for celiacs for more options! Also, here is the price history so you know exactly when to buy!

Price history for Basigano on Amazon

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