18 Best Multivitamins with Methylfolate for Your Health

Discover the best multivitamin with methylfolate for optimal wellness, crafted to boost your health swiftly and simply with top-performing nutrients.
BrandMy RatingPrice
Envitamin
Top Frugal Selection
8.6/10
Smartypants
Best for Immune Support
9.0/10
Pure Encapsulations
Best for Cognitive Function
9.2/10
Thorne
Best for Natural Absorption
8.6/10
Thorne
9.2/10

Best Multivitamin with Methylfolate

Looking for a multivitamin that offers more than just the basics? Dive into our curated selection of the best multivitamin with methylfolate, where nourishing your body with essential nutrients becomes a swift, satisfying journey. Whether you're boosting brain power or supporting overall wellness, we've got the perfect pick to elevate your daily routine.

Top Frugal Selection: Envitamin

Ultimate Multivitamin Multimineral and Superfood with 42 Fruit and Vegetable Blend, 60 Count
Highlights
Liquid capsule for absorption
Contains 23 vitamins and minerals
Includes fruit and vegetable blend

Ultimate Multivitamin by envitamin shines with its unique liquid capsule format, ensuring maximum absorption—a real game-changer for bioavailability.

Packed with 23 essential vitamins and minerals plus a proprietary blend of 42 fruits and vegetables, it offers comprehensive support in a small, convenient package.

While it’s a bit modest in size and slightly lean on vitamin content compared to pricier options, its affordability makes it perfect for budget-conscious shoppers.

Overall, this multivitamin proves that you don’t need to spend a fortune for high-quality, effective daily support.

Be sure to also check out the best multivitamin without gelatin for more options! Also, here is the price history so you know exactly when to buy!

Price history for Envitamin on Amazon

Best for Immune Support: SmartyPants

SmartyPants Women's Multivitamin Gummies: Omega 3 Fish Oil (EPA/DHA), Methylfolate, CoQ10, Vitamin D3, C, Vitamin B12, B6, A, K & Zinc, Inositol, Gluten Free, 180 Count (30 Day Supply)
Highlights
High-quality, science-backed ingredients
Delicious natural flavors
Third-party tested for purity

This gummy is a powerhouse of 21 nutrients, expertly formulated for women with busy lifestyles.

We love that it uses bioavailable forms like methylfolate and methylcobalamin, making absorption a breeze for your body.

The added Vitamin D3 and Zinc boost immune support, earning it our "Best for Immune Support" badge.

Plus, the natural blueberry, orange, and lemon crème flavors make taking your daily dose a treat — even if you’re not a fan of sticky textures or metallic tastes.

Overall, it offers a delicious, reliable, and clean option for anyone looking to fill their nutrient gaps efficiently.

Be sure to also check out the best multivitamin for vegan female for more options! Also, here is the price history so you know exactly when to buy!

Price history for SmartyPants on Amazon

Best for Cognitive Function: Pure Encapsulations O.N.E. Multivitamin

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 60 Capsules
Highlights
High bioavailability
Supports cognitive health
Free from common allergens

**Pure Encapsulations’ O.

N.

E.

Multivitamin** truly shines as the best for cognitive function, thanks to its well-rounded blend of brain-boosting ingredients like lutein, zeaxanthin, and CoQ10, paired with methylfolate for optimal mental clarity.

It offers high bioavailability, meaning your body absorbs these nutrients efficiently — a big plus for busy individuals.

Plus, it supports overall eye and cellular health while being free from common allergens.

The distinct odor and higher price tag are minor downsides given its premium formulation.

Overall, a smart choice for mental sharpness!

Be sure to also check out the best multivitamin for vegetarians for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Encapsulations O.N.E. Multivitamin on Amazon

Best for Natural Absorption: Thorne Basic Nutrients 2/Day

THORNE Basic Nutrients 2/Day - Comprehensive Daily Multivitamin with Optimal Bioavailability - Vitamin & Mineral Formula - Gluten, Dairy & Soy-Free - 60 Capsules - 30 Servings
Highlights
High absorption nutrients
Third-party tested
Trusted brand

Formulated with highly bioavailable forms of vitamins, including methylated B-vitamins and minerals, this supplement truly lives up to its label as the "Best for Natural Absorption." The third-party testing certification guarantees purity, giving us confidence in what’s inside each capsule.

While some users might find the smell a bit strong or experience mild nausea if taken on an empty stomach, the fundamental support for heart, brain, immune, and skin health is clear.

For those prioritizing bioavailability and trusted quality, this is a stellar choice.

Be sure to also check out the best multivitamin for pcos for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne Basic Nutrients 2/Day on Amazon

Thorne

THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine - Gluten, Dairy & Soy-Free - 90 Capsules
Highlights
Supports methylation
Active B vitamins
Trusted high-quality brand

Methyl-Guard Plus by Thorne stands out with its active forms of B vitamins and methylated folate, ensuring optimal absorption and support for healthy methylation.

It’s a powerhouse for maintaining homocysteine levels and promoting overall wellness.

Plus, it's free from common allergens like gluten, dairy, and nuts, making it a versatile choice for various diets.

Trusted by elite athletes and backed by collaboration with Mayo Clinic, Thorne's quality is second to none.

Though a bit on the pricier side, its premium ingredients make it worth considering for those serious about their supplement game.

Be sure to also check out the best multivitamin for shih tzu for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne on Amazon

Triquetra Methyl Folate

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
Highlights
High potency dosage
Bioactive methylfolate form
Supports brain and mood

Its high-potency 15mg of L-Methylfolate ensures potent support for methylation, making it ideal for those with absorption concerns or methylation issues.

The inclusion of Methylcobalamin B12 creates a dynamic duo that boosts energy, sharpens focus, and stabilizes mood.

Since methylfolate is in its active 5-MTHF form, it’s quickly absorbed and ready to work, especially beneficial for individuals with folate metabolism challenges.

While some users might experience mild heartburn, the benefits for brain health, cardiovascular support, and nerve function make it a premium choice for health-conscious supplement seekers.

Be sure to also check out the best multivitamin for women with pcos for more options! Also, here is the price history so you know exactly when to buy!

Price history for Triquetra Methyl Folate on Amazon

Igennus Multivitamin with Methylfolate

Igennus Methylated Women's Multivitamin, Methylated Folate for MTHFR, Clean Label & Sustained Release, with Iron, Non-GMO, Halal, 60 Vegan Tablets
Highlights
Bioavailable methylfolate
Easy to swallow
Supports energy & immunity

The bioavailable methylfolate stands out, easily crossing cell membranes to deliver maximum benefits.

The formula is crafted with clean, hypoallergenic ingredients—no fillers or synthetic junk here—so it's gentle yet effective.

The high-potency blend of iron, B-vitamins, and essential nutrients provides all-day support for energy, immunity, and hormone balance.

Plus, the sustained-release tablets ensure steady nutrient absorption throughout the day.

While it’s ideal for many women, postmenopausal users should note the iron content might not be suitable.

Overall, a premium choice for those seeking faster, targeted results in their multivitamin.

Be sure to also check out the best probiotic with butyrate for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus on Amazon

Pure Therapro Rx Methyl Multi

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps
Highlights
High absorption bioavailability
Supports MTHFR mutations
No artificial ingredients

The Pure TheraPro Rx Methyl Multi without Iron stands out with its superior absorption thanks to pre-methylated B12 and methylfolate, ideal for those with MTHFR mutations.

Made from high-quality, no-artificial ingredients, it’s a clean, vegan-friendly choice backed by rigorous third-party testing.

The capsules are designed for maximum bioavailability, ensuring your body gets what it needs efficiently.

Keep in mind, some may experience mild detox symptoms — patience and gradual dosing are key.

Overall, it’s a robust, thoughtfully formulated supplement perfect for supporting total wellness and vitality.

Be sure to also check out the best women's multivitamin without iodine for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Therapro Rx Methyl Multi on Amazon

Inessa

Inessa Methylated Multivitamin for Men - Advanced Natural Daily Mens Multivitamins with CoQ10 100mg, Vitamins D3, K2, A, B Complex Vitamins, Folic Acid & Zinc - 60 Vegan Tablets for Men & Women
Highlights
Feels Effective and Boosts Mood
Comprehensive Nutrient Profile
Vegan and Allergen-Free

This multivitamin truly feels effective, boosting both mood and energy levels thanks to its comprehensive nutrient profile.

With 25 highly bioavailable ingredients—including methylfolate, K2, and D3—it simplifies your daily routine by replacing multiple supplements.

Plus, it's vegan, allergen-free, and free from unnecessary additives, which makes it perfect for those who prioritize clean eating.

However, be prepared for a strong odor and a fluorescent urine color—quirks to know before you buy.

While it’s on the pricier side, the potent mix of nutrients can make it well worth the investment for sustained vitality and wellness.

Be sure to also check out the best bariatric multivitamin with iron for more options! Also, here is the price history so you know exactly when to buy!

Price history for Inessa on Amazon

Primal Harvest Multivitamin with Methylfolate

Primal Harvest Primal Multivitamin - Daily Multi-Vitamin Supplement with 21 Essential Vitamins & Minerals for Women & Men - Vitamin A, C, D, E, B12, B6, Biotin, Folic Acid, Zinc, Copper & Selenium
Highlights
Complete vitamin blend
Supports energy levels
Clean, gluten-free formula

The Primal Multivitamin packs a punch with a comprehensive blend of 21 essential nutrients that boost energy, support immunity, and promote overall wellness.

Its clean, gluten-free formula aligns with diverse dietary needs, making it a reliable daily companion.

While it has a strong odor and only 1 capsule per day, it still provides targeted support without unnecessary fillers.

Keep in mind, its limited iron content might not suit everyone, but for those looking for a straightforward, well-rounded multivitamin, it’s a solid choice to energize your day and keep your health on track.

Be sure to also check out the best berberine with ceylon cinnamon for more options! Also, here is the price history so you know exactly when to buy!

Price history for Primal Harvest on Amazon

SmartyPants

SmartyPants Multivitamin for Men, Gummies: Omega 3 Fish Oil (EPA/DHA), Methylfolate, CoQ10, Vitamin D3, C, Vitamin B12, B6, A, K & Zinc for Immune Support, Biotin, 180 Gummies (30 Day Supply)
Highlights
Delicious tasting gummies
High-quality, bioavailable nutrients
Third-party tested purity

SmartyPants Men's Multi & Omegas packs a punch with its delicious lemon crème, blueberry, and blackberry flavors—taking the hassle out of supplementing.

The gummies contain bioavailable nutrients like methylfolate and methylcobalamin, making absorption a breeze for your body.

Plus, it's third-party tested and awards like the Clean Label Project ensure you're getting a clean, safe product.

Just a heads-up, you’ll need to enjoy six gummies daily, and some organic versions may have a fishy aftertaste.

Overall, a tasty, trustworthy option for supporting your daily health!

Be sure to also check out the best magnesium threonate gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for SmartyPants on Amazon

Double Wood Methylated Multivitamin

Methylated Multivitamin (Methylated and Activated Vitamins Only - B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood
Highlights
Methylated, bioavailable vitamins
Supports healthy homocysteine
Suitable for MTHFR mutation

… Double Wood’s Methylated Multivitamin delivers only activated, bioavailable forms of essential vitamins—perfect for anyone needing support for MTHFR mutations or trying to optimize their homocysteine levels.

The inclusion of methylated B12, B6, and B2, along with methylated folate, ensures your body can actually use these nutrients without extra conversion steps.

Plus, it’s flexible—can be stacked with other multivitamins for a customized boost.

While the price is a bit higher, the quality and targeted support make it a smart choice for a clean, effective supplement routine.

Be sure to also check out the best vitamin d3 in olive oil for more options! Also, here is the price history so you know exactly when to buy!

Price history for Double Wood Methylated Multivitamin on Amazon

Best Nest Wellness Men’s Multi Plus Multivitamin with Methylfolate

Best Nest Wellness Men's Multi Plus - Daily Multivitamin for Brain & Energy Health Support - Daily Multivitamin for Men - Probiotics & Digestive Enzyme Formula - 30 Caplets
Highlights
Contains methylfolate
Supports brain health
Includes probiotics

This multivitamin is tailored specifically for men, providing a comprehensive blend that supports everything from brain health to energy.

The inclusion of methylfolate and methylcobalamin really sets it apart, helping to boost focus, memory, and overall mental clarity.

Plus, with probiotics and digestive enzymes, it’s gentle on the stomach and promotes gut health.

The convenient once-daily caplet makes sticking to your routine effortless.

Just a heads-up—the flavor can be a bit strong, so those sensitive to taste might want to consider that.

Overall, a solid choice for men looking for an effective, all-in-one supplement.

Be sure to also check out the best vitamins for sensitive stomach for more options! Also, here is the price history so you know exactly when to buy!

Price history for Best Nest Wellness Men’s Multi Plus on Amazon

Thorne

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 1mg
Highlights
Supports methylation health
Boosts energy and mood
Trusted quality brand

Thorne’s multivitamin with methylfolate is a powerhouse for supporting healthy methylation, which is crucial for energy, mood, and cellular health.

It also promotes positivity and helps maintain nerves and circulation — essential for overall well-being.

Plus, with its focus on cardiovascular support by aiding homocysteine metabolism, it ticks all the right boxes.

As a trusted brand used by professional sports teams and collaborating with Mayo Clinic, Thorne offers dependable quality.

Though the review count is limited, its 4.7-star rating speaks volumes for those seeking premium, research-backed supplementation.

Be sure to also check out the best vitamins for lactating dogs for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne on Amazon

Igennus Kids Multivitamin

Igennus Methylated Kids Multivitamin Gummy, MTHFR Supplement with B-Vitamins & Vitamin D, No Artificial Sweeteners or Flavors, Sugar Free, Age 4+, 90 Berry Gummies, Non-GMO, Halal, Clean Label
Highlights
High absorption nutrients
Clean, hypoallergenic ingredients
Great taste for kids

These gummies pack a punch with higher potency than your average multivitamin, delivering a solid boost of 11 essential vitamins and minerals, including methylated B-vitamins like folate and methylcobalamin B12, which are optimized for better absorption.

The clean, hypoallergenic formula means no artificial colors, flavors, or preservatives — perfect for health-conscious families.

Plus, their delicious berry flavor makes them a favorite among kids, turning supplement time into a treat.

The only caveat is that the potency might be too intense for some, so always start with the recommended dosage.

Be sure to also check out the best bariatric multivitamin chewable for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus Kids Multivitamin on Amazon

Envitamin

Multivitamin with Methylfolate

Methylated Multivitamin Multimineral Complex L Methylfolate
Highlights
Contains methylated folate
High vitamin content
Easy to swallow capsules

The Methylated B12 and 5-MTHF make it a fantastic choice for those looking to support healthy methylation processes.

The easy-to-swallow capsules are a plus for anyone who dislikes pills, and the high vitamin content ensures you're getting essential micronutrients in one convenient scoop.

While it may not be as comprehensive as some other multivitamins, its targeted formula is perfect for busy lifestyles.

Just keep in mind the limited reviews and potential taste considerations.

Overall, a solid option for a methylfolate-rich multivitamin that’s quick and easy to incorporate into your routine.

Be sure to also check out the best vitamin d for bariatric patients for more options! Also, here is the price history so you know exactly when to buy!

Price history for Envitamin  
on Amazon

Igennus Methylated Men’s Multivitamin

Igennus Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, 21 Highly Bioavailable Nutrients, Multivitamin for Sustained Release, Clean Label, Non-GMO & Halal 60 Tablets
Highlights
High absorption formula
Methylated B-vitamins
Slow-release technology

The methylated, bioactive forms of B-vitamins and other essential nutrients ensure optimal absorption, giving your cells a quick boost.

The slow-release formula distributes nutrients steadily throughout the day, maintaining balanced levels without the peaks and crashes.

Designed specifically for men, it offers a comprehensive mix of 22 high-potency ingredients minus the unnecessary fillers.

Plus, its clean, vegan-friendly profile and lab-verified ingredients make it a trustworthy choice.

While it skips magnesium and comes at a slightly higher price, its efficiency and quality make it a savvy pick for health-conscious men seeking reliable support.

Be sure to also check out the best liquid multivitamin men for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus Methylated Men’s Multivitamin on Amazon

Pure Therapro Rx

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 60-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 120 Caps
Highlights
High absorption bioavailability
Supports MTHFR mutations
No artificial ingredients

Pure TheraPro Rx Methyl Multi without Iron delivers high absorption with its pre-methylated forms of B12 and Folate, making it ideal for those with MTHFR mutations.

Its clean, vegan-friendly formula is free from artificial fillers, ensuring you get only the good stuff.

We appreciate the careful formulation, promoting total-body wellness and supporting cognitive and detox functions.

However, new users should start slow, as some may experience detox symptoms—a sign your body is adapting.

Overall, this supplement is a top-choice for bioavailability and purity, perfect for anyone prioritizing quality and effective absorption.

Be sure to also check out the best vitamin b12 supplement for dogs for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Therapro Rx on Amazon

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