12 Probiotics for Colic Relief You Can Trust

Discover the best probiotic for colic to soothe your little one. Quick, clear insights into top options for happy, calm babies.
BrandMy RatingPrice
Biogaia
Best for Soothing Colic
9.0/10
Pink Stork
Best for Gentle Digestion
8.8/10
Biogaia
Best for Soothing Colic
9.0/10
Maryruth Organics
Smart Budget Choice
9.2/10
Lovebug Probiotics
8.6/10

Best Probiotic for Colic

Struggling to soothe a colicky baby can feel like navigating a whirlwind of sleepless nights and endless worries. Discovering the perfect probiotic can bring a gentle, calming tide to your routine, helping restore balance and comfort. In this guide, we'll explore the best probiotic options to ease colic and bring peaceful days back to your little one.

Best for Soothing Colic: BioGaia

BioGaia Protectis Baby Probiotic Drops | Baby Essentials for Colic & Gas Relief | Safe for Newborns | Ease Crying, Fussing, Colic, Gas, Spit-ups & Constipation | No Dairy, Soy & Gluten | 5mL
Highlights
Soothes colic & fussiness
Safe for newborns
Natural breast milk ingredients

BioGaia Protectis Baby Probiotic Drops are the most studied probiotic for colic, with a proven track record of calming fussiness and soothing tiny tummies.

Made from natural ingredients found in breast milk, it’s safely suited for newborns from day one, whether breastfed or bottle-fed.

While it may take a few days to notice a difference, many parents appreciate its gentle, natural approach without any artificial additives.

Though the servings are limited, the reassuring DIY of scientifically validated relief makes BioGaia our top choice for colic soothing.

Be sure to also check out the best probiotic for lactose intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for BioGaia on Amazon

Best for Gentle Digestion: Pink Stork Baby Probiotics

Pink Stork Baby Probiotic Drops, Newborn, Infant & Toddler Probiotics to Help Aid Digestion and Constipation Support, Newborn Essentials - 1 fl oz, 2 Month Supply
Highlights
Supports digestion and immune health
Easy no-drip syringe
Vegan and non-GMO

Pink Stork Baby Probiotic Drops earn our spot as the "Best for Gentle Digestion." Packed with Lactobacillus rhamnosus, the most-studied probiotic strain for little tummies, these drops are a gentle way to support your baby's digestive system and reduce fussiness from gas or constipation.

The no-drip syringe makes dosing a breeze, and the vegan, non-GMO formula reassures health-conscious parents.

While a few have reported packaging leakage, overall, this probiotic has shown promise in promoting gastrointestinal balance and immune health.

A reliable choice for your baby's comfort!

Be sure to also check out the best probiotics for liver for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pink Stork Baby Probiotics on Amazon

Smart Budget Choice: MaryRuth Organic

MaryRuth Organics USDA Organic Infant Liquid Probiotic Drops | Baby Essentials | Probiotics for Infants | Baby Probiotic Drops | Proprietary Probiotic Blend | Vegan | Non GMO | 125 Servings
Highlights
Supports infant digestion
Unflavored, easy administration
Organic and clean label

MaryRuth Organics USDA Organic Infant Liquid Probiotic Drops offer a robust blend of five probiotic strains, including Bacillus coagulans Unique IS-2, tailored specifically for a baby's delicate digestion.

The unflavored, easy-to-administer liquid makes it a hassle-free choice for busy parents.

Plus, with certifications like USDA Organic, Vegan, and Clean Label Project, it reassures us of its quality.

While the CFU count per dose is modest, this product provides gentle yet effective support for your infant's developing gut—a smart budget-friendly choice for nurturing your little one's health.

Be sure to also check out the best probiotic for histamine intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for MaryRuth Organic on Amazon

Lovebug Probiotics

Lovebug Award Winning USDA Organic Probiotic for Infants & Babies | Helps with Colic, Reflux, Diarrhea, Constipation & Gas | Multi-Strain 5 Billion CFU | Liquid Drops | Ages 0-24 Months
Highlights
Effective digestive relief
Includes vitamin D
Easy to incorporate

Lovebug’s probiotic is formulated specifically for babies aged 0-12 months, addressing common issues like colic, gas, and digestive upset with six clinically studied strains.

The fact that it’s USDA Organic Certified and sugar-free means you can trust it’s safe and pure—no artificial ingredients or allergens here!

It also includes vitamin D, which is a bonus for immune support.

While the drops dispense quickly and lack a precise dosing dropper, the ease of use and effective relief make it a top choice for busy parents.

Overall, Lovebug’s gentle, high-quality formula is trusted by many moms for soothing little tummies.

Be sure to also check out the best probiotic for mouth ulcers for more options! Also, here is the price history so you know exactly when to buy!

Price history for Lovebug Probiotics on Amazon

Culturelle Baby

Culturelle Baby Digestive Calm & Comfort Probiotic (Age 0-12 Mos) 8.5Ml, Helps Periodic Colic, Gas, Fussiness, Crying & Digestive Upset In Infants & Newborns, Vegan Non-Gmo Gluten-Free, 1 Mos. Supply
Highlights
Clinically studied probiotics
Supports healthy digestion
Safe for infants

Culturelle Baby Digestive Calm + Comfort Drops is from the #1 pediatrician-recommended probiotic brand, making it a top choice for anxious parents.

Its formulation contains clinically studied probiotics like Lactobacillus rhamnosus GG, proven to help ease occasional tummy troubles and reduce fussiness caused by colic.

Plus, it’s safe for daily use in infants from birth to 12 months, supporting healthy development in the crucial early months.

While the dropper could be a bit easier to use, its gentle ingredients and trusted reputation make it a reliable go-to for soothing your little one’s stomach.

Be sure to also check out the best probiotic for iron absorption for more options! Also, here is the price history so you know exactly when to buy!

Price history for Culturelle Baby  
on Amazon

Mommy's Bliss Probiotic for Colic

Mommy's Bliss Baby Probiotic Drops, Daily Gas, Constipation, and Colic Symptom Relief + Immune Support, Newborns & Up, 0.34 Fl Oz (30 Servings)
Highlights
Supports digestion
Recommended by pediatricians
Easy to administer

Mommy's Bliss Baby Probiotic Drops Everyday is trusted by pediatricians and easy for parents to incorporate into daily routines.

Its gentle liquid form makes administering to little ones a breeze, which is a huge plus during those hectic colic moments.

While some babies might experience minor gas, most find the drops soothing over time.

The small bottle size means it’s convenient to carry around, making it perfect for on-the-go use.

Overall, this probiotic strikes a lovely balance between effectiveness and simplicity, helping to support your baby's digestive health with minimal fuss.

Be sure to also check out the best probiotic for low fodmap for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mommy's Bliss on Amazon

BioGaia Protectis Baby

BioGaia Protectis Baby Probiotic Drops | Colic & Gas Relief + Vitamin D | Safe for Newborns | Ease Crying, Fussing, Colic, Gas, Spit-ups & Constipation | No Dairy, Soy & Gluten | 50 Day Supply | 10mL
Highlights
Relieves colic symptoms
Safe for newborns
Naturally found in breast milk

BioGaia Baby has a proven track record spanning over 20 years for soothing fussiness, colic, and gas in infants.

Its gentle, scientifically validated probiotic is naturally found in breast milk, making it a trusted choice for parents seeking safe relief from digestive discomfort.

Ideal for newborns from day one, it helps calm crying, fussiness, and gassiness without the use of artificial ingredients.

While it’s on the pricier side and dosing can require some attention, its safety profile and efficacy make it a stand-out option for a happy, comfortable tummy.

Be sure to also check out the best probiotic for bv for more options! Also, here is the price history so you know exactly when to buy!

Price history for BioGaia Protectis Baby on Amazon

Culturelle Probiotics for Babies

Culturelle Probiotics for Babies, Colic plus Soothing Drops From Culturelle, Helps Soothe Colic, Fussiness and Crying in Babies 0-12 Months, 7.5ml drops, One Month's Supply
Highlights
Helps soothe baby
Supports digestive health
Easy to administer

Culturelle Baby Colic plus offers a safe and gentle solution tailored specifically for little ones.

Its probiotic strains work naturally to help reduce fussiness and crying caused by digestive upset, providing quick comfort.

Plus, it includes 100% of the daily vitamin D needs, supporting your baby's bone strength and immune health. Ease of use is a big plus—just five drops a day, directly into the mouth or a bottle, makes life easier for busy parents.

While the bottle is small and can leak during travel, its trusted ingredients and proven benefits make it a top contender for calming babies with colic.

Be sure to also check out the best probiotics for sleep for more options! Also, here is the price history so you know exactly when to buy!

Price history for Culturelle Probiotics for Babies on Amazon

MaryRuth Organics Baby Probiotic Drops Probiotic for Colic

MaryRuth Organics Baby Probiotic Drops | Liquid Precision Probiotics for Digestive Health | Colic Calm | Occasional Colic Baby Relief | USDA Organic | Vegan | Baby Essentials| 30 Servings
Highlights
Clinically studied strains
Supports colic symptoms
Organic & Non-GMO

MaryRuth's Organic Infant Probiotic Drops contain a carefully selected blend of clinically studied strains like Pediococcus pentosaceus and Bifidobacterium longum, which are shown to support gut health and reduce colic symptoms.

The organic, non-GMO, and allergen-free formula makes it a safe choice for delicate newborns.

While the application can be a bit messy due to its greasy consistency, many parents appreciate the ease of adding just a few drops to their baby's daily routine.

Overall, a solid, gentle option to help soothe your little one's fussiness.

Be sure to also check out the best probiotic for hemorrhoids for more options! Also, here is the price history so you know exactly when to buy!

Price history for MaryRuth Organics Baby Probiotic Drops on Amazon

Mylicon

Infants' Mylicon Daily Probiotic Drops, for Colic and Fussiness, 8mL, 21 Daily Doses
Highlights
Reduces crying fussiness
Supports immune health
Easy to use

Infants' Mylicon Daily Probiotic Drops are a game-changer for fussier little ones.

They effectively reduce crying and fussiness when used daily, giving parents much-needed relief.

Beyond soothing, these drops support a healthy gut and boost immune defenses—super important for growing infants.

They're versatile and easy to incorporate into a feeding routine: add to breastmilk, formula, or apply directly.

Plus, they’re free from common allergens and artificial ingredients, making them a safe choice.

The only minor hiccup?

They require refrigeration and a fresh start every 28 days, but the benefits for your baby's well-being make it worth it.

Be sure to also check out the best probiotics for gallbladder for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mylicon on Amazon

Wellements Baby Probiotic

Wellements Organic Baby Probiotic Drops (0.25 Fl Oz) - Digestive & Immune Support for Infants - Toddler Probiotic Helps with Newborn+ Gut Health, Gas, Constipation & Colic Support - Preservative Free
Highlights
Supports digestive health
Easy to administer drops
Certified organic ingredients

Wellements Organic Probiotic Drops make supporting your little one's gut health simple and stress-free.

Crafted from high-quality, certified organic ingredients like LactoSpore Bacillus coagulans and organic MCT oil, they are gentle yet powerful.

The odorless, tasteless drops easily mix into feeds, making administration a breeze—no fuss, no mess.

While it’s on the pricier side and requires refrigeration, the peace of mind knowing you're giving a clean, allergen-free product makes it worthwhile.

For parents seeking a reliable, no-nonsense probiotic, these drops are a solid choice to soothe colic and promote overall healthy digestion.

Be sure to also check out the best probiotic for fertility for more options! Also, here is the price history so you know exactly when to buy!

Price history for Wellements Baby Probiotic on Amazon

Mommy's Bliss Probiotic for Colic

Mommy's Bliss Baby Probiotic Drops + Vitamin D, Supports Digestive Health and Immunity, 400IU Vitamin D for Healthy Bone Development, Newborns +, Flavorless, 0.34 Fl Oz (30 Servings)
Highlights
Easy to administer
Tasteless drops
Supports digestion

Mommy's Bliss Baby Probiotic Drops + Vitamin D are gentle, safe, and easy to use — perfect for delicate baby tummies.

Since they’re tasteless and come in a liquid drop form, administering them is a breeze, and parents won't have to wrestle with unpleasant flavors.

The probiotic strain used is one of the most researched, giving us peace of mind that it’s effective for supporting digestion.

While the limited reviews mean we recommend caution, its pediatrician approval and reputation for calming colic make it a top contender for new parents seeking quick, reliable relief.

Be sure to also check out the best probiotic for prostate for more options! Also, here is the price history so you know exactly when to buy!

Price history for Mommy's Bliss on Amazon

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