18 Methylated Multivitamins That Boost Your Wellness

Discover the best methylated multivitamins with quick, expert picks to boost your health effortlessly. Find your perfect match today.
BrandMy RatingPrice
Thorne
Superior Budget Option
8.6/10
Power by Naturals
Best for MTHFR Support
9.2/10
Pure Encapsulations
Best for Cognitive Health
9.4/10
Wild Foods
Best for Energy Boost
8.8/10
10x Health System
9.2/10

Best Methylated Multivitamins

Looking to elevate your wellness game with methylated multivitamins, the key players that unlock better absorption and targeted support? Dive into our curated picks that deliver nature's potency in a swift, streamlined package—perfect for those who crave efficiency without sacrificing quality. Discover the best options and boost your health journey today.

Superior Budget Option: Thorne

THORNE Basic Nutrients 2/Day - Comprehensive Daily Multivitamin with Optimal Bioavailability - Vitamin & Mineral Formula - Gluten, Dairy & Soy-Free - 60 Capsules - 30 Servings
Highlights
High bioavailability nutrients
Trusted quality brand
Comprehensive formula

As the "Superior Budget Option," Thorne's methylated multivitamin delivers big value without breaking the bank.

It’s packed with highly bioavailable forms of essential vitamins like A, B’s, C, D, E, and K—perfect for supporting overall health, brain, immune, and bone wellness.

Plus, it’s third-party tested, so you know exactly what you're getting—trust is key! While some users might find the smell strong or feel a bit queasy on an empty stomach, these minor inconveniences are outweighed by its comprehensive benefits and trusted reputation.

Overall, it’s an affordable, reliable choice for those seeking top-quality methylated nutrients.

Be sure to also check out the best methylated multivitamin for women over 50 for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne on Amazon

Best for MTHFR Support: Power By Naturals Methyl Multi

Power By Naturals Methyl Multi One - Iron-Free Methylated Multivitamin with Quatrefolic 5-MTHF, Active B12, P5P, CoQ10 & Zinc for MTHFR Support - Energy & Focus Formula - 60 Capsules (2-Month Supply)
Highlights
Enhanced energy and focus
Supports MTHFR gene variants
High bioavailability ingredients

This methylated multivitamin is specifically formulated with targeted support for MTHFR mutations, making it a game-changer for those with genetic variants.

Its blend of bioavailable methylated B12, 5-MTHF, and cofactors ensures your body absorbs vital nutrients efficiently.

Plus, with added antioxidants like CoQ10 and ALA, it promotes overall vitality.

While some might notice a strong vitamin scent or a change in urine odor, these are minor quirks in exchange for a comprehensive daily supplement that supports methylation health.

Overall, a reliable and potent choice!

Be sure to also check out the best methylated multivitamin for men over 50 for more options! Also, here is the price history so you know exactly when to buy!

Price history for Power By Naturals Methyl Multi on Amazon

Best for Cognitive Health: Pure Encapsulations O.N.E.

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 120 Capsules
Highlights
Highly bioavailable vitamins
Supports cognitive health
Free from allergens

*Pure Encapsulations' O.

N.

E.

Multivitamin* earns its spot as our top choice for cognitive health.

With highly bioavailable forms of vitamins A, B, C, D, and E, it ensures your body can absorb what it needs efficiently.

The addition of antioxidants like lutein, zeaxanthin, and lycopene specifically targets brain and eye health, supporting long-term cognitive longevity.

Plus, it’s free from common allergens and artificial ingredients, making it a clean and trustworthy option.

Heads up—its distinct odor and possible moisture sensitivity are minor quirks that don’t detract from its benefits.

Be sure to also check out the best methylated magnesium for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Encapsulations O.N.E. on Amazon

Best for Energy Boost: Wild Methylated Multivitamin

Wild Methylated Multivitamin for Women & Men | Daily Multi Vitamin | MTHFR Supplement Without Iron | Methylated B12, Folate, Vitamin C, A, K2, D, E, Choline, Biotin, ALA, CoQ10 & More (60 Capsules)
Highlights
Active methylated forms
Comprehensive nutrient blend
Supports overall health

Wild Foods' methylated multivitamins are formulated for enhanced absorption, thanks to active B12 and methyl folate that ensure your body soaks up every nutrient.

Packed with a comprehensive blend of 27 essential vitamins, minerals, and antioxidants, it supports whole-body health, from immune function to cardiovascular wellness.

Made in the USA with high-quality standards, this supplement is a reliable choice for boosting vitality.

While the cheesy aroma and higher price might be a small caveat, the powerful nutrient profile makes it a top pick for energy-conscious folks seeking real results.

Be sure to also check out the best vegan multivitamin gummies for more options! Also, here is the price history so you know exactly when to buy!

Price history for Wild Methylated Multivitamin on Amazon

10X Health System

10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules
Highlights
Enhanced methylation support
High-quality USA-made
Increased energy levels

10X Optimize truly delivers targeted nutritional support by addressing genetic gaps in your methylation pathway.

The inclusion of essential methylated nutrients like 5-MTHF and methylated B12 ensures your body’s methylation processes stay smooth and efficient, boosting overall wellness.

The addition of vital minerals like magnesium and zinc helps maintain vital balance, supporting immune function and mental clarity.

Plus, the inclusion of NAC adds an extra layer of cellular defense, promoting antioxidant health.

Made proudly in the USA, this supplement stands out for its quality assurance.

While some may need to watch B12 levels or side effects, it’s an excellent choice for those seeking optimized methylation support with a high-quality edge.

Be sure to also check out the best liposomal multivitamin for more options! Also, here is the price history so you know exactly when to buy!

Price history for 10X Health System on Amazon

Double Wood Methylated Multivitamin

Methylated Multivitamin (Methylated and Activated Vitamins Only - B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood
Highlights
Highly bioavailable forms
Supports MTHFR mutation
Can be combined with regular Vits

Double Wood's Methylated Multivitamin features activated, bioavailable forms of essential vitamins, ensuring your body can absorb and use them immediately—no need for conversions.

It packs a punch with six methylated vitamins, including the crucial MTHFR-supporting folate, making it a solid choice for those with genetic mutations.

Plus, it can seamlessly be stacked with your usual multivitamin to cover gaps or boost coverage.

While the price is a bit higher, the quality and support for methylation health make it worth considering.

Overall, a reliable, well-sourced option for methylation support.

Be sure to also check out the best liquid multivitamin men for more options! Also, here is the price history so you know exactly when to buy!

Price history for Double Wood Methylated Multivitamin on Amazon

Pure Therapro Rx Methylated Multivitamins

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 60-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 120 Caps
Highlights
High absorption formulation
Supports MTHFR mutations
Pure, additive-free ingredients

Pure TheraPro Rx Methyl Multi without Iron stands out with its high absorption formulation, thanks to pre-methylated nutrients and Albion TRAACS chelates.

It’s especially beneficial for those with MTHFR mutations, helping support proper methylation processes and energy metabolism.

Plus, it’s free from artificial fillers, making it a clean, hypoallergenic choice.

That said, some users may experience a temporary detox reaction — so starting slow and increasing dosage gradually is wise.

Overall, a top-tier multivitamin for total wellness enthusiasts looking for bioavailability, safety, and purity.

Be sure to also check out the best bariatric multivitamin chewable for more options! Also, here is the price history so you know exactly when to buy!

Price history for Pure Therapro Rx on Amazon

Envitamin Multivitamin

Womens Methylated Multivitamin Multimineral Horsetail, Iron, Biotin Complex with L Methylfolate for Ultra Absorption
Highlights
Contains methylated B12
Includes Iron and Omega 3
Effective for energy

The Women's Methylated Multivitamin Complex by envitamin delivers key nutrients like methylated B12, 5-MTHF, and Inositol, which are fantastic for supporting energy and brain health.

The added Iron and Omega-3 boost its appeal, making it a well-rounded choice for busy women.

While the vitamin content is on the lower side, its effectiveness lies in targeted methylation support, which many users find beneficial.

The compact packaging and USA-made quality add extra peace of mind.

Overall, it's a solid pick for those seeking a straightforward, methylated multivitamin without unnecessary extras.

Be sure to also check out the best halal vitamins for more options! Also, here is the price history so you know exactly when to buy!

Price history for Envitamin Multivitamin on Amazon

Envitamin

Methylated Multivitamin Multimineral Complex L Methylfolate
Highlights
Contains methylated B12
High in daily vitamins
Easy to swallow capsules

The Methylated Multivitamin Complex by envitamin offers a well-rounded blend of essential nutrients, including methylated B12 and 5-MTHF, which are fantastic for those supporting methylation and brain health.

The capsules are easy to swallow, making daily intake hassle-free.

While the vitamin content is solid, it might fall short for those needing a higher dose of certain nutrients.

With a high rating and popularity in the market, this multivitamin is perfect for anyone seeking comprehensive micronutrient coverage in a convenient, USA-made formula.

Be sure to also check out the best gnc men's multivitamin for more options! Also, here is the price history so you know exactly when to buy!

Price history for Envitamin on Amazon

Micro Ingredients Pure Methylated Multivitamin Methylated Multivitamins

Pure Methylated Multivitamin | 240 Capsules with Vitamins C, D, B12, Thiamin, Folate + Magnesium, Zinc, & More | High Absorption | Bioactive Vitamin & Mineral Complex | Filler Free
Highlights
High bioavailability
No fillers or additives
Comprehensive nutrient support

Micro Ingredients' Pure Methylated Multivitamin Complex delivers a highly bioavailable blend of 19 active nutrients, ensuring your body absorbs what it needs efficiently.

With no fillers, soy, dairy, or gluten, it’s a clean choice for those with sensitivities or seeking purity.

The inclusion of essential methylated vitamins like B12 (methylcobalamin) and folate helps support energy, heart, and brain health seamlessly.

While it comes at a premium price and has a limited flavor profile, its comprehensive formula passes our safety tests and offers maximum potency for optimal health support.

Be sure to also check out the best bariatric multivitamin with iron for more options! Also, here is the price history so you know exactly when to buy!

Price history for Micro Ingredients Pure Methylated Multivitamin on Amazon

Inessa

Inessa Methylated Multivitamin for Men - Advanced Natural Daily Mens Multivitamins with CoQ10 100mg, Vitamins D3, K2, A, B Complex Vitamins, Folic Acid & Zinc - 60 Vegan Tablets for Men & Women
Highlights
Feel Better Quickly
Comprehensive Ingredient List
Vegan & Allergen Free

… This multivitamin truly feels like a wellness upgrade—packed with 25 highly bioavailable ingredients designed to boost your energy and overall vitality.

The blend acts like an antioxidant, B-complex, CoQ10, D3, and K2 all in one, making daily health both simple and effective.

Plus, its vegan, allergen-free formulation aligns perfectly with clean eating goals.

While the strong odor and vibrant urine color might catch you off guard, the quick noticeable benefits and comprehensive profile make it worth the investment for those serious about feeling their best every day.

Be sure to also check out the best nest vitamins for more options! Also, here is the price history so you know exactly when to buy!

Price history for Inessa on Amazon

Igennus Methylated Men’s Multivitamin

Igennus Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, 21 Highly Bioavailable Nutrients, Multivitamin for Sustained Release, Clean Label, Non-GMO & Halal 60 Tablets
Highlights
High absorption formula
Slow-release technology
Methylated & active forms

The methylated and active nutrient forms ensure maximum bioavailability, helping your body absorb the essential vitamins and minerals more efficiently.

The slow-release formula keeps your nutrient levels steady throughout the day, reducing the need for multiple doses.

Designed specifically for men, it includes 22 high-potency nutrients, bolstered with antioxidants like lycopene, without any iron—perfect if you're avoiding excess iron.

Plus, the clean, vegan, lab-verified ingredients and recyclable packaging make it a trustworthy choice.

While it lacks magnesium and has some label clarity quirks, it remains a top-tier, effective multivitamin for those seeking premium, targeted support.

Be sure to also check out the best multivitamin for vegetarians for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus Methylated Men’s Multivitamin on Amazon

Igennus Methylated Multivitamins

Igennus Methylated Women's Multivitamin, Methylated Folate for MTHFR, Clean Label & Sustained Release, with Iron, Non-GMO, Halal, 60 Vegan Tablets
Highlights
Bioavailable methylated forms
Clean, vegan & non-GMO
Enhanced absorption technology

The methylated and active forms of each nutrient ensure optimal absorption and delivery right to your cells, making it a powerhouse for energy, immunity, and mood support.

The clean, vegan, non-GMO ingredients mean you get pure quality without unnecessary fillers—no silicon dioxide or magnesium stearate here!

Plus, the sustained-release technology keeps nutrients in your bloodstream all day long, providing reliable coverage with just two small tablets.

While it’s a fantastic choice for many women, those who are postmenopausal might want to consider other options.

Overall, a well-rounded, effective multivitamin for everyday vitality.

Be sure to also check out the best multivitamin for pcos for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus on Amazon

NatureGenX Methylated Multivitamin

Just One Daily Methylated Multivitamin - 60 Caps Pure Methyl B12, Methylfolate MTHFR Support Supplement Iron Free Methylated Vitamins for Men & Women 2 Months Supply Gluten Free
Highlights
Highly absorbable nutrients
Suitable for MTHFR mutation
No artificial additives

NatureGenX’s Methylated Multivitamin delivers superior absorption thanks to its bioactive, body-ready vitamins—perfect for those with or without the MTHFR mutation.

It packs a balanced mix of 27 nutrients into a convenient one-capsule daily dose, supporting everything from immune health to cardiovascular wellness.

Made proudly in the USA, it’s free from artificial additives and designed for optimal safety and quality.

The only downside?

A rather strong vinegar odor and taste that might take some getting used to.

Still, it’s a great choice for anyone seeking quick, effective support.

Be sure to also check out the best multivitamin for runners for more options! Also, here is the price history so you know exactly when to buy!

Price history for NatureGenX Methylated Multivitamin on Amazon

Eliixr Methylated Multivitamin

Eliixr Methylated Multivitamin Supplement for Men and Women with Active Methyl B12 and 5-MTHF Methylfolate 60 Vegetable Capsules Iron Free Made in The USA
Highlights
Supports methylation processes
Contains essential B vitamins
Includes antioxidants and micronutrients

The advanced methylation support with active 5-MTHF and methylcobalamin ensures your body's methylation pathways stay smooth and efficient, boosting energy and reducing homocysteine levels.

The blend of seven essential B vitamins—including biotin and pyridoxine—makes it a powerhouse for brain health, energy, and overall vitality.

Plus, packed with antioxidants like CoQ10 and lutein, it covers your bases in a single, convenient capsule.

The natural variations in smell and color are normal and don’t affect quality, which is a plus for purity-conscious users.

Overall, a trustworthy, comprehensive multivitamin for adults seeking targeted methylation support.

Be sure to also check out the best multivitamin with methylfolate for more options! Also, here is the price history so you know exactly when to buy!

Price history for Eliixr Methylated Multivitamin on Amazon

Igennus Methylated Kids Multivitamin Methylated Multivitamins

Igennus Methylated Kids Multivitamin Gummy, MTHFR Supplement with B-Vitamins & Vitamin D, No Artificial Sweeteners or Flavors, Sugar Free, Age 4+, 90 Berry Gummies, Non-GMO, Halal, Clean Label
Highlights
High absorption nutrients
Clean, hypoallergenic formula
Great taste for kids

The Igennus Methylated Multivitamin Gummy packs a punch with higher potency than typical gummies, delivering essential vitamins like A, C, D, and E, along with vital minerals such as iodine, zinc, and methylated B-vitamins.

The bioactive forms ensure excellent absorption, making these particularly beneficial for those with MTHFR mutations or absorption issues.

Plus, the clean, vegan, hypoallergenic ingredients make it safe and gentle for kids, with a delicious mixed berry flavor that they love.

While it’s more expensive and limited in variety, it’s a top choice for supporting growth, immunity, and brain health in children.

Be sure to also check out the best multivitamin without gelatin for more options! Also, here is the price history so you know exactly when to buy!

Price history for Igennus Methylated Kids Multivitamin on Amazon

Life Extension One Per Day Multivitamin

Life Extension One-Per-Day Multivitamin – Packed with Over 25 Vitamins, Minerals & Plant Extracts, Quercetin, 5-MTHF Folate & More – 1-Daily, Non-GMO, Gluten-Free – 60 Tablets
Highlights
Complete nutrient coverage
Supports immune health
High-quality ingredients

The One-Per-Day Multivitamin from Life Extension offers complete nutrient coverage, meeting and even surpassing the RDA for essential vitamins and minerals like biotin, vitamins A through E, iodine, thiamine, and selenium.

It supports immune health with potent doses of vitamins C and D3, while the quality ingredients—most of which are non-GMO and gluten-free—give us confidence in its potency and purity.

The only hurdles?

The large pill size and sometimes strong odor might require some patience.

Overall, a well-rounded choice for a scientifically backed daily health boost.

Be sure to also check out the best allergen free multivitamin for more options! Also, here is the price history so you know exactly when to buy!

Price history for Life Extension One Per Day Multivitamin on Amazon

PrimeMD Methylated B Complex

Methylated B Complex with Methylfolate and B12 Methylcobalamin 1000 mcg - Methylated Multivitamin for Energy, Brain Function, and Wellness - Vitamin B Complex for Men & Women (90 Servings) (Pack of 1)
Highlights
High bioavailability absorption
Energy and focus boost
No artificial fillers

PrimeMD's Methylated B Complex delivers eight bioactive B vitamins, including a potent 1000mcg of methylcobalamin B12—perfect for a vibrant, energized life.

This formula boasts high bioavailability, ensuring your body absorbs what it needs quickly and efficiently.

It’s free from artificial flavors, fillers, and preservatives, aligning well with a holistic health mindset.

While the price might give you pause, the potential for improved energy, mental clarity, and overall well-being makes it a worthwhile investment, especially if you’re committed to daily consistency.

Be sure to also check out the best methylated b12 and folate for more options! Also, here is the price history so you know exactly when to buy!

Price history for PrimeMD Methylated B Complex on Amazon

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