19 Probiotics to Lower Cortisol and Calm Your Mind

Discover the best probiotic to lower cortisol and chill your stress levels naturally. Find your perfect gut-friendly match for a calmer, healthier you.
BrandMy RatingPrice
Wholesome Wellness
Best Price-to-Performance
9.0/10
Nouri
Best for Stress Reduction
8.8/10
Garden of Life
Best for Gut-Brain Connection
9.2/10
Mabefy
Best for Adrenal Support
9.2/10
Physician's Choice
9.0/10

Best Probiotic to Lower Cortisol

Struggling with stress and cortisol spikes? Discover the uproar of probiotic superheroes that can gently restore your balance from the inside out. In this quick guide, we'll unveil the best probiotic allies to help lower cortisol levels and bring zen back into your busy life.

Best Price-to-Performance: Wholesome Wellness

Wholesome Wellness Dr. Formulated Raw Probiotics for Women 100 Billion CFUs Capsules with Prebiotics, Digestive Enzymes, Approved for Adults, Shelf Stable Supplement
Highlights
Contains 34 probiotic strains
High potency 100B CFU
Supports gut & immune health

This probiotic boasts a huge 100 billion CFUs per serving, making it a powerhouse for gut and immune support.

With 34 doctor-selected strains, it covers a broad spectrum of benefits, even supporting urinary health with added cranberry extract.

The shelf-stable, easy-to-swallow capsules make daily use a breeze, and it's crafted in the USA with high-quality, vegan, and gluten-free ingredients.

While it’s not specifically formulated to target cortisol, many users report improved stress resilience thanks to better gut health.

Overall, a top-tier choice for exceptional value, blending potency with convenience.

Be sure to also check out the best probiotic for fertility for more options! Also, here is the price history so you know exactly when to buy!

Price history for Wholesome Wellness on Amazon

Best for Stress Reduction: Nouri

Daily Nouri Stress Probiotic | for Cortisol Management, Digestion, Daily Stress Relief & Gut Microbiome Health | 3 Probiotic Strains & Vegan Ahiflower Omega Oil | for Women & Men | 30-Day Supply
Highlights
Supports stress response
Probiotic with Omega-3
Capsule-in-capsule design

The Stress Support Probiotic by Nouri really stands out as "Best for Stress Reduction" thanks to its thoughtful blend of probiotics and adaptogens like Ashwagandha and L-Theanine.

It’s designed to influence the gut-brain axis directly, helping to destabilize unwanted bacteria while bolstering good bacteria that support mood and cortisol management.

Plus, the capsule-in-capsule delivery ensures the probiotics survive stomach acid and reach deeper into your gut for maximum benefit.

The addition of vegan Omega-3 oil makes it a well-rounded choice.

Just be prepared for possible initial gas and a longer shipping wait!

Be sure to also check out the best probiotics for osteoporosis for more options! Also, here is the price history so you know exactly when to buy!

Price history for Nouri on Amazon

Best for Gut-Brain Connection: Garden of Life

Garden of Life Probiotics Mood+ Dr Formulated Acidophilus Probiotic Supplement - Promotes Emotional Well-Being, Relaxation and Digestive Balance - Ashwagandha for Stress Management, 60 Veggie Caps
Highlights
Supports mood & relaxation
Shelf-stable & potent
Includes stress-relief ingredients

As the best for gut-brain connection in our lineup, it combines a robust 50 billion CFU from 16 different strains—clinically studied for mood support—with natural stress-relievers like organic Ashwagandha and blueberries.

The inclusion of prebiotics feeds your gut's good bacteria, which in turn helps regulate cortisol levels naturally.

Plus, it’s shelf-stable and manufactured with high quality standards (think non-GMO and gluten-free).

While some users might need to give it a bit more time to see full results, its potent blend and dual focus on digestion and stress make it a top choice for anyone seeking mood balance and cortisol management in one convenient capsule.

Be sure to also check out the best probiotics for sleep for more options! Also, here is the price history so you know exactly when to buy!

Price history for Garden of Life on Amazon

Best for Adrenal Support: MABEFY Cortisol Supplement

Cortisol Supplement - 10 in 1 Cortisol Manager with Magnesium, Ashwagandha, L-Theanine, Cortisol Health & Stress Relief, Lower Cortisol for Women - 60 Vegetarian Capsules
Highlights
Natural, vegan ingredients
Supports relaxation and calm
Enhances cortisol regulation

This supplement shines as the best for adrenal support thanks to its thoughtful blend of herbs and nutrients.

The combination of Ashwagandha, Rhodiola, and Magnesium works synergistically to target adrenal health and cortisol regulation, helping you stay calm under pressure.

Plus, the inclusion of Phosphatidylserine boosts cognitive clarity, making this ideal for those seeking mental sharpness along with stress relief.

Its natural, vegan formulation ensures you're nurturing your body without unnecessary fillers or chemicals.

While long-term use may be needed for full effects, it’s a trustworthy, high-quality choice for maintaining cortisol balance.

Be sure to also check out the best probiotic for hemorrhoids for more options! Also, here is the price history so you know exactly when to buy!

Price history for MABEFY Cortisol Supplement on Amazon

Physician's Choice Probiotics

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 30ct
Highlights
Supports gut health
Survives in gut
Backed by science

This Max Strength General Purpose Probiotic packs a powerful punch with 60 billion CFU and 10 diverse strains, specifically designed to support overall gut health.

Its acid-resistant capsules and shelf-stable packaging ensure maximum survival through your digestive journey, making it a reliable choice for those aiming to nurture a balanced microbiome.

While it isn't tailored specifically for cortisol reduction, a healthy gut has been linked to lower stress levels and improved hormonal balance, which may help in managing cortisol.

Plus, backed by scientific research and third-party tested for purity, it earns its spot as a solid, science-backed supplement to incorporate into your daily routine.

Be sure to also check out the best probiotic for prostate for more options! Also, here is the price history so you know exactly when to buy!

Price history for Physician's Choice Probiotics on Amazon

Thorne Adrenal Cortex

THORNE Adrenal Cortex - Supplement for Cortisol Management - Support Healthy Adrenal Gland Function, Immune System, Stress Management, Fatigue & Metabolism - 60 Capsules
Highlights
Supports stress regulation
Boosts energy levels
Trusted by professionals

Thorne’s adrenal support supplement is formulated to nourish your adrenal glands, helping you stay resilient in a high-stress world.

It includes a unique extract designed to promote healthy stress regulation and maintain immune function, all while giving you an energetic boost when you need it most.

Trusted by professionals and backed by research collaborations with the Mayo Clinic, Thorne offers a reliable choice for balancing cortisol levels.

While some users might need to tweak the dosage, it’s definitely a solid option for anyone seeking a mental edge and stress relief in a convenient capsule.

Be sure to also check out the best probiotic for mouth ulcers for more options! Also, here is the price history so you know exactly when to buy!

Price history for Thorne Adrenal Cortex on Amazon

OmniBiotics Cortisol Support Probiotic to Lower Cortisol

OmniBiotics Cortisol Supplement for Women and Men, High Cortisol Manager with Ashwagandha, L-Theanine, Magnolia Extract, Phosphatidylserine to Support Relaxation, Calm, Detox, 60 Vegan Capsules
Highlights
Promotes calm and relaxation
Natural, vegan ingredients
Supports restful sleep

OmniBiotics Cortisol Relax champions a holistic approach with a blend of natural herbs and adaptogens like Ashwagandha, Rhodiola, and Lemon Balm—all known for promoting a calming effect.

It’s designed to help you maintain a healthy cortisol response, making it a solid choice for balancing daily stress and supporting restful sleep.

Plus, it's completely vegan, non-GMO, and free from additives, ensuring you get pure, high-quality ingredients.

While it may cause some drowsiness and results can vary, it’s a great option for those seeking natural stress relief and enhanced relaxation.

Be sure to also check out the best probiotics for tonsil stones for more options! Also, here is the price history so you know exactly when to buy!

Price history for OmniBiotics Cortisol Support on Amazon

LES Labs Cortisol Health

LES Labs Cortisol Health – Stress Relief, Balanced Cortisol Response, Relaxation & Deep Sleep – Phosphatidylserine, Magnesium, Magnolia Bark, Rhodiola Rosea & Ashwagandha – Non-GMO – 60 Capsules
Highlights
Promotes restful sleep
Natural stress support
Calming and relaxation

Cortisol Health is designed to help regulate that pesky stress hormone while promoting restful sleep — all without the need for drugs.

Its natural blend of ingredients like ashwagandha, rhodiola, magnesium, and phosphatidylserine work together to promote relaxation and support your body's response to mental and physical stress.

We especially appreciate how it aims for a balanced cortisol response, helping you stay calm under pressure.

While it might be a bit pricier and could cause over-sedation for some, if you're after a natural, holistic approach to stress relief, this is a solid choice.

Be sure to also check out the best probiotic for low fodmap for more options! Also, here is the price history so you know exactly when to buy!

Price history for LES Labs Cortisol Health on Amazon

LUCNVEM Cortisol Gummies

Cortisol Supplements Gummies for Women, Magnesium Ashwagandha Rhodiola Rosea and L-theanine Complex for Women, Maintain Healthy Cortisol Levels - 30 Day Vegan Supply
Highlights
Tasteful apple flavor
Supports sleep & mood
Easy gummy form

**LUCNVEM's women-specific formula offers a thoughtful blend of adaptogenic herbs like ashwagandha and Rhodiola, combined with calming L-theanine and magnesium to support healthy cortisol levels naturally.

The delicious apple-flavored gummies make daily compliance a breeze—no more swallowing pills or dealing with unpleasant powders.

Plus, the inclusion of phosphatidylserine encourages cognitive clarity while promoting restful sleep, ideal for women juggling busy lives.

While it's tailored just for women, its quality and taste make it a standout option for anyone looking to balance stress and boost mental wellness effortlessly.

Be sure to also check out the best prebiotic powders for more options! Also, here is the price history so you know exactly when to buy!

Price history for LUCNVEM Cortisol Gummies on Amazon

Integrative Therapeutics Cortisol Manager Probiotic to Lower Cortisol

Integrative Therapeutics - Cortisol Manager - Supplement with Ashwagandha and L-Theanine - Supports Relaxation & Calm* - 30 Tablets
Highlights
Supports stress response
Calms mind for sleep
Trusted quality brand

The Cortisol Manager by Integrative Therapeutics is a reliable choice for those seeking to balance stress hormones naturally.

Its blend of Sensoril ashwagandha and L-theanine helps promote a calm state and support restful sleep, making it ideal for managing stress's toll on your body.

We appreciate the trusted quality of this brand, backed by over 35 years of experience.

However, some users might experience vivid dreams or find the potency inconsistent. Still, it’s a solid, science-backed option for lowering cortisol levels smoothly.

Be sure to also check out the best probiotics postpartum for more options! Also, here is the price history so you know exactly when to buy!

Price history for Integrative Therapeutics Cortisol Manager on Amazon

Align

Align Probiotic, Pro Formula, Probiotics for Women and Men, Daily Probiotic Supplement, Helps Soothe Occasional Bloating & Gas*, #1 Doctor Recommended Brand‡, 63 Capsules (Packaging May Vary)
Highlights
Scientifically backed strain
Helps digestive health
Recommended by doctors

Align Probiotic stands out with its 2x concentrated formula, delivering the same powerful CFU count in a smaller, super easy-to-swallow capsule.

Backed by over 20 years of scientific research, it contains the unique probiotic strain Bifidobacterium 35624, which is developed by gastroenterologists.

Not only does it help build and support a healthy digestive system, but many users report soothing occasional bloating and discomfort.

While the price is a bit high, the doctor-recommended status and proven science make it a top contender for those seeking cortisol-lowering benefits through improved gut health.

Be sure to also check out the best probiotics for liver for more options! Also, here is the price history so you know exactly when to buy!

Price history for Align on Amazon

NutraHarmony

Cortisol Supplement for Women - Natural Based Hormone Balance - Ashwagandha | Rhodiola | Holy Basil | L-Theanine - Mood, Focus & Sleep Support - Made in USA - Vegan, Non-GMO - 60 Capsules for 2 Month
Highlights
Reduces stress and anxiety
Improves sleep quality
All-natural ingredients

The Cortisol Support Complex by NutraHarmony is crafted with a thoughtful blend of herbs, vitamins, and minerals that work in harmony to reduce stress and promote relaxation.

The inclusion of Vitamin B6, B12, and Magnesium helps boost resilience, while L-theanine provides a calming effect.

Users frequently notice better sleep and lower anxiety levels—making it a solid choice for those seeking cortisol balance.

Plus, because it's made in the USA, you can trust the quality and standards behind this natural formula. It’s a smart, effective addition to your stress-management arsenal!

Be sure to also check out the best probiotics for gallbladder for more options! Also, here is the price history so you know exactly when to buy!

Price history for NutraHarmony on Amazon

HOLLEGEND Cortisol Gummies Probiotic to Lower Cortisol

Cortisol Gummies for Women, Sugar-Free Lower Cortisol Supplement with Ashwagandha, Magnesium, L-theanine, Phosphatidylserine, Vitamin B6 for Relaxation, Sleep, Focus, Vegan, 60
Highlights
Supports cortisol balance
Contains adaptogen herbs
Delivers mental clarity

These gummies pack a powerful punch with ingredients like magnesium glycinate and ashwagandha, both known for their stress-busting abilities.

The addition of phosphatidylserine and vitamin B6 boosts brain health and energy, making it a well-rounded option for combating cortisol spikes.

Plus, the proprietary blend of Holy Basil, Rhodiola, and other adaptogens adds an extra layer of stress resistance.

The blueberry flavor makes them easy to enjoy, and the vegan, GMO-free formula aligns with health-conscious lifestyles.

While results can vary, we appreciate how this supplement combines natural ingredients for mental clarity and relaxation.

Be sure to also check out the best probiotics for fibromyalgia for more options! Also, here is the price history so you know exactly when to buy!

Price history for HOLLEGEND Cortisol Gummies on Amazon

BBEEAAUU

Cortisol Supplements for Women & Men - 10-in-1 Cortisol Reducer Manager Detox with Ashwagandha, Magnesium - Lower High Cortisol Levels, Relaxation & Night Support, Non-GMO, 120 Capsules
Highlights
Supports Stress Reduction
Natural, Non-GMO Ingredients
Suitable for All Genders

BBEEAAUU’s cortisol balance capsules boast a powerful 10-in-1 formula, meticulously crafted to help naturally lower cortisol levels.

With ingredients like Ashwagandha, Rhodiola, and L-Theanine, it targets stress at its root, promoting relaxation and better sleep.

The non-GMO, vegetarian-friendly profile ensures a clean, safe choice for everyone.

Plus, the 60-day supply makes it a convenient long-term option.

While results can vary and consistency is key, this supplement’s holistic approach makes it an excellent pick for calming the mind and supporting overall well-being.

Be sure to also check out the best probiotics for alcohol drinkers for more options! Also, here is the price history so you know exactly when to buy!

Price history for BBEEAAUU on Amazon

Integrative Therapeutics Cortisol Manager

Integrative Therapeutics Cortisol Manager - Allergen-Free - Supplement with Ashwagandha and L-Theanine - Supports Relaxation & Calm to Support Restful Sleep* - 30 Tablets
Highlights
Supports cortisol balance
Includes stress-relief ingredients
Vegan and allergen-free

The blend of L-theanine and Sensoril ashwagandha offers a solid foundation for managing stress and supporting cortisol balance.

The vegan formulation and allergen-free guarantee make it accessible for many, and its compact size makes daily dosing a breeze.

While some users report mixed results—so it might take a bit of patience—there's enough consistent positive feedback to consider it seriously.

Overall, this supplement is a thoughtful choice for those seeking a plant-based, stress-supporting option that aligns with a holistic wellness plan.

Be sure to also check out the best probiotic for histamine intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for Integrative Therapeutics Cortisol Manager on Amazon

Jarrow Formulas Probiotic to Lower Cortisol

Jarrow Formulas Probiotics 10 Billion CFU - Probiotic Supplement Capsules for Gut Health for Women and Men, 120 Veggie Capsules, Up to 60 Days
Highlights
Supports digestive health
Survives stomach acid
Vegetarian & Non-GMO

Jarrow Probiotics boast a blend of 8 clinically studied strains that support gut health and help soothe occasional bloating, gas, and discomfort.

Thanks to their EnteroGuard coating, these capsules are engineered to survive digestion and deliver probiotics right where they’re needed.

With 120 vegetarian, non-GMO capsules, they offer great value and convenience without refrigeration.

While they haven’t been explicitly linked to cortisol reduction in reviews, a healthy gut has been shown to positively influence stress levels overall.

Plus, their NSF certification assures quality control.

Be sure to also check out the best probiotic for lactose intolerance for more options! Also, here is the price history so you know exactly when to buy!

Price history for Jarrow Formulas on Amazon

Nature Target Probiotics

NATURE TARGET Probiotics for Women-Men-Kids Digestive Health, Prebiotics and Probiotics for Women, 100 Billion for Gut and Immune Health, No Refrigeration, 90 Veggie Capsules (45 Days Supply)
Highlights
High CFU count (100 billion)
Broad spectrum of 30 strains
No refrigeration needed

With an impressive 100 billion CFUs and 30 diverse strains, it packs a potent punch for overall gut and immune support.

The proprietary colon cleanse complex and prebiotic fiber boost digestion and help reduce bloating, which can indirectly support cortisol balance by calming stress-related gut issues.

Plus, its enteric coating means it can withstand stomach acid, ensuring high absorption.

While it doesn't target cortisol directly, its broad-spectrum support for gut health and immune function makes it a smart choice for those seeking hormone harmony through digestive wellness.

Be sure to also check out the best probiotic for breastfeeding moms for more options! Also, here is the price history so you know exactly when to buy!

Price history for Nature Target Probiotics on Amazon

B Beworths

Cortisol Supplements, 10-In-1 Cortisol Manager with Magnesium, Ashwagandha, L-Theanine, Rhodiola, Lower Cortisol for Women Men - Balanced Cortisol Levels for Stress Manage, Night Support, 120 Capsules
Highlights
Holistic stress support
Easy to swallow capsules
Vegan and Non-GMO

The blend of adaptogenic herbs like Ashwagandha and rhodiola provides a robust foundation for managing stress, while the added vitamins support cortisol reduction on a cellular level.

The formulation promotes a sense of calm, helping you unwind and enjoy restorative sleep, without the grogginess.

Plus, the capsules are vegan and non-GMO, fitting seamlessly into most dietary routines.

While some may need patience for full results and the price is a bit higher, the holistic approach and high-quality ingredients make this a standout choice for anyone aiming to lower cortisol naturally.

Be sure to also check out the best probiotic for sugar cravings for more options! Also, here is the price history so you know exactly when to buy!

Price history for B Beworths on Amazon

AMENQ hHEALTH Cortisol Support Probiotic to Lower Cortisol

Cortisol Supplements for Women & Men, 16-in-1 Cortisol Reducer Detox Manager w. Magnesium, Ksm-66 Ashwagandha, L-Theanine, Rhodiola, Phosphatidylserine for Lower Cortisol, Mood, Focus, Sleep Support
Highlights
Natural stress reduction
Enhanced sleep quality
Rapid liquid absorption

The Ultimate Cortisol Supplement from AMENQ hHealth stands out with its powerful blend of 16 carefully selected ingredients, like Ashwagandha and Rhodiola, which are renowned for their stress-busting properties.

The addition of Phosphatidylserine supports mental clarity, making it perfect for those juggling everything.

Its liquid drops formulation ensures rapid absorption—so you feel calmer and sleep better faster than with capsules or gummies.

Plus, the lemon flavor makes daily dosing a breeze.

While long-term data is still emerging, its holistic approach to lowering cortisol and enhancing relaxation earns it our top spot for busy lifestyles.

Be sure to also check out the best probiotic for iron absorption for more options! Also, here is the price history so you know exactly when to buy!

Price history for AMENQ hHEALTH Cortisol Support on Amazon

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